Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador

María Fernanda Zurita; Paúl A. Cárdenas; María Elena Sandoval; María Caridad Peña; Marco Fornasini; Nancy Flores; Marcia H. Monaco; Kirsten Berding; Sharon M. Donovan; Thomas Kuntz; Jack A. Gilbert; Manuel E. Baldeón

doi:10.1080/19490976.2019.1662260

Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador

María Fernanda Zurita
, Paúl A. Cárdenas
, María Elena Sandoval
, María Caridad Peña
, Marco Fornasini
, Nancy Flores
, Marcia H. Monaco
, Kirsten Berding
, Sharon M. Donovan
, Thomas Kuntz
, Jack A. Gilbert
, Manuel E. Baldeón^*

^*Corresponding author for this work

Universidad Técnica de Ambato
Universidad de las Americas - Ecuador
Universidad Andina Simón Bolívar
Universidad Tecnológica Equinoccial
University of Illinois at Urbana-Champaign
University of Chicago

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Most studies on autism spectrum disorder (ASD) risk factors have been conducted in developed countries where ethnicity and environment are different than in developing countries. We compared nutritional status, immune response and microbiota composition in mestizo children with ASD with matched controls in Ecuador. Twenty-five cases and 35 controls were matched by age, sex and school location. The prevalence of under- and overweight was higher in children with ASD. Nutritional differences were accompanied by abnormal food habits and more frequent gastrointestinal symptoms in children with ASD. Also, greater serum concentrations of TGF-β1 were observed in children with ASD. Finally, there was greater alpha diversity and abundance of Bacteroides (2 OTUs), Akkermansia, Coprococcus and different species of Ruminococcus in ASD children.

Original language	English
Pages (from-to)	453-464
Number of pages	12
Journal	Gut Microbes
Volume	11
Issue number	3
DOIs	https://doi.org/10.1080/19490976.2019.1662260
State	Published - 3 May 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Autism spectrum disorder
Ecuador
behavior
immunity
microbiota
nutrition

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10.1080/19490976.2019.1662260

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Zurita, M. F., Cárdenas, P. A., Sandoval, M. E., Peña, M. C., Fornasini, M., Flores, N., Monaco, M. H., Berding, K., Donovan, S. M., Kuntz, T., Gilbert, J. A., & Baldeón, M. E. (2020). Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador. Gut Microbes, 11(3), 453-464. https://doi.org/10.1080/19490976.2019.1662260

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abstract = "Most studies on autism spectrum disorder (ASD) risk factors have been conducted in developed countries where ethnicity and environment are different than in developing countries. We compared nutritional status, immune response and microbiota composition in mestizo children with ASD with matched controls in Ecuador. Twenty-five cases and 35 controls were matched by age, sex and school location. The prevalence of under- and overweight was higher in children with ASD. Nutritional differences were accompanied by abnormal food habits and more frequent gastrointestinal symptoms in children with ASD. Also, greater serum concentrations of TGF-β1 were observed in children with ASD. Finally, there was greater alpha diversity and abundance of Bacteroides (2 OTUs), Akkermansia, Coprococcus and different species of Ruminococcus in ASD children.",

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AU - Zurita, María Fernanda

AU - Cárdenas, Paúl A.

AU - Sandoval, María Elena

AU - Peña, María Caridad

AU - Fornasini, Marco

AU - Flores, Nancy

AU - Monaco, Marcia H.

AU - Berding, Kirsten

AU - Donovan, Sharon M.

AU - Kuntz, Thomas

AU - Gilbert, Jack A.

AU - Baldeón, Manuel E.

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AB - Most studies on autism spectrum disorder (ASD) risk factors have been conducted in developed countries where ethnicity and environment are different than in developing countries. We compared nutritional status, immune response and microbiota composition in mestizo children with ASD with matched controls in Ecuador. Twenty-five cases and 35 controls were matched by age, sex and school location. The prevalence of under- and overweight was higher in children with ASD. Nutritional differences were accompanied by abnormal food habits and more frequent gastrointestinal symptoms in children with ASD. Also, greater serum concentrations of TGF-β1 were observed in children with ASD. Finally, there was greater alpha diversity and abundance of Bacteroides (2 OTUs), Akkermansia, Coprococcus and different species of Ruminococcus in ASD children.

KW - Autism spectrum disorder

KW - Ecuador

KW - behavior

KW - immunity

KW - microbiota

KW - nutrition

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DO - 10.1080/19490976.2019.1662260

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JO - Gut Microbes

JF - Gut Microbes

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ER -

Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador

Abstract

UN SDGs

Keywords

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