Co-delivery of hydrophobic and hydrophilic drugsfrom nanoparticle-aptamer bioconjugates

Liangfang Zhang; Aleksandar F. Radovic-Moreno; Frank Alexis; Frank X. Gu; Pamela A. Basto; Vaishali Bagalkot; Sangyong Jon; Robert S. Langer; Omid C. Farokhzad

doi:10.1002/cmdc.200700121

Co-delivery of hydrophobic and hydrophilic drugsfrom nanoparticle-aptamer bioconjugates

Liangfang Zhang
, Aleksandar F. Radovic-Moreno
, Frank Alexis
, Frank X. Gu
, Pamela A. Basto
, Vaishali Bagalkot
, Sangyong Jon
, Robert S. Langer
, Omid C. Farokhzad

Massachusetts Institute of Technology
Brigham and Women's Hospital
Gwangju Institute of Science and Technology

Research output: Contribution to journal › Article › peer-review

262 Scopus citations

Abstract

(Figure Presented) Herein we report a novel targeted drug delivery system consisting of nanoparticle-aptamer bioconjugates,which can carry both hydrophobic and hydrophilic chemotherapeutic drugs simultaneously, and deliver them selectively in a targeted and temporally distinct manner. This work provides a robust platform for targeted co-delivery of chemotherapeutic agents with the hope of both leveraging the synergistic effects of multiple drugs and also potentially suppressing the likelihood of drug resistance by the treated tissues.

Original language	English
Pages (from-to)	1268-1271
Number of pages	4
Journal	ChemMedChem
Volume	2
Issue number	9
DOIs	https://doi.org/10.1002/cmdc.200700121
State	Published - 10 Sep 2007
Externally published	Yes

Keywords

Antitumor agents
Conjugation
Dual drug delivery
Nanoparticles
Targeted therapy

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10.1002/cmdc.200700121

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title = "Co-delivery of hydrophobic and hydrophilic drugsfrom nanoparticle-aptamer bioconjugates",

abstract = "(Figure Presented) Herein we report a novel targeted drug delivery system consisting of nanoparticle-aptamer bioconjugates,which can carry both hydrophobic and hydrophilic chemotherapeutic drugs simultaneously, and deliver them selectively in a targeted and temporally distinct manner. This work provides a robust platform for targeted co-delivery of chemotherapeutic agents with the hope of both leveraging the synergistic effects of multiple drugs and also potentially suppressing the likelihood of drug resistance by the treated tissues.",

keywords = "Antitumor agents, Conjugation, Dual drug delivery, Nanoparticles, Targeted therapy",

author = "Liangfang Zhang and Radovic-Moreno, \{Aleksandar F.\} and Frank Alexis and Gu, \{Frank X.\} and Basto, \{Pamela A.\} and Vaishali Bagalkot and Sangyong Jon and Langer, \{Robert S.\} and Farokhzad, \{Omid C.\}",

year = "2007",

month = sep,

day = "10",

doi = "10.1002/cmdc.200700121",

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T1 - Co-delivery of hydrophobic and hydrophilic drugsfrom nanoparticle-aptamer bioconjugates

AU - Zhang, Liangfang

AU - Radovic-Moreno, Aleksandar F.

AU - Alexis, Frank

AU - Gu, Frank X.

AU - Basto, Pamela A.

AU - Bagalkot, Vaishali

AU - Jon, Sangyong

AU - Langer, Robert S.

AU - Farokhzad, Omid C.

PY - 2007/9/10

Y1 - 2007/9/10

N2 - (Figure Presented) Herein we report a novel targeted drug delivery system consisting of nanoparticle-aptamer bioconjugates,which can carry both hydrophobic and hydrophilic chemotherapeutic drugs simultaneously, and deliver them selectively in a targeted and temporally distinct manner. This work provides a robust platform for targeted co-delivery of chemotherapeutic agents with the hope of both leveraging the synergistic effects of multiple drugs and also potentially suppressing the likelihood of drug resistance by the treated tissues.

AB - (Figure Presented) Herein we report a novel targeted drug delivery system consisting of nanoparticle-aptamer bioconjugates,which can carry both hydrophobic and hydrophilic chemotherapeutic drugs simultaneously, and deliver them selectively in a targeted and temporally distinct manner. This work provides a robust platform for targeted co-delivery of chemotherapeutic agents with the hope of both leveraging the synergistic effects of multiple drugs and also potentially suppressing the likelihood of drug resistance by the treated tissues.

KW - Antitumor agents

KW - Conjugation

KW - Dual drug delivery

KW - Nanoparticles

KW - Targeted therapy

UR - https://www.scopus.com/pages/publications/42349106952

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DO - 10.1002/cmdc.200700121

M3 - Artículo

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AN - SCOPUS:42349106952

SN - 1860-7179

VL - 2

SP - 1268

EP - 1271

JO - ChemMedChem

JF - ChemMedChem

IS - 9

ER -

Co-delivery of hydrophobic and hydrophilic drugsfrom nanoparticle-aptamer bioconjugates

Abstract

Keywords

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