Defining CT Perfusion Thresholds for Infarction in the Golden Hour and with Ultra-Early Reperfusion

Mohamed Najm; Fahad S. Al-Ajlan; Mari E. Boesen; Lisa Hur; Chi Kyung Kim; Enrico Fainardi; Michael D. Hill; Andrew M. Demchuk; Mayank Goyal; Ting Y. Lee; Bijoy K. Menon

doi:10.1017/cjn.2017.287

Defining CT Perfusion Thresholds for Infarction in the Golden Hour and with Ultra-Early Reperfusion

Mohamed Najm
, Fahad S. Al-Ajlan
, Mari E. Boesen
, Lisa Hur
, Chi Kyung Kim
, Enrico Fainardi
, Michael D. Hill
, Andrew M. Demchuk
, Mayank Goyal
, Ting Y. Lee
, Bijoy K. Menon^*

^*Corresponding author for this work

University of Calgary
University of Calgary
Western University
Korea University
King Faisal Specialist Hospital and Research Centre
Foothills Medical Centre
Azienda Ospedaliera Careggi

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

In this brief report, computed tomography perfusion (CTP) thresholds predicting follow-up infarction in patients presenting <3 hours from stroke onset and achieving ultra-early reperfusion (<45 minutes from CTP) are reported. CTP thresholds that predict follow-up infarction vary based on time to reperfusion: Tmax >20 to 23 seconds and cerebral blood flow <5 to 7 ml/min ^-1 /(100 g) ^-1 or relative cerebral blood flow <0.14 to 0.20 optimally predicted the final infarct. These thresholds are stricter than published thresholds.

Original language	English
Pages (from-to)	339-342
Number of pages	4
Journal	Canadian Journal of Neurological Sciences
Volume	45
Issue number	3
DOIs	https://doi.org/10.1017/cjn.2017.287
State	Published - 1 May 2018
Externally published	Yes

Keywords

CT perfusion
early reperfusion
endovascular therapy

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10.1017/cjn.2017.287

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title = "Defining CT Perfusion Thresholds for Infarction in the Golden Hour and with Ultra-Early Reperfusion",

abstract = " In this brief report, computed tomography perfusion (CTP) thresholds predicting follow-up infarction in patients presenting <3 hours from stroke onset and achieving ultra-early reperfusion (<45 minutes from CTP) are reported. CTP thresholds that predict follow-up infarction vary based on time to reperfusion: Tmax >20 to 23 seconds and cerebral blood flow <5 to 7 ml/min -1 /(100 g) -1 or relative cerebral blood flow <0.14 to 0.20 optimally predicted the final infarct. These thresholds are stricter than published thresholds.",

keywords = "CT perfusion, early reperfusion, endovascular therapy",

author = "Mohamed Najm and Al-Ajlan, \{Fahad S.\} and Boesen, \{Mari E.\} and Lisa Hur and Kim, \{Chi Kyung\} and Enrico Fainardi and Hill, \{Michael D.\} and Demchuk, \{Andrew M.\} and Mayank Goyal and Lee, \{Ting Y.\} and Menon, \{Bijoy K.\}",

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month = may,

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doi = "10.1017/cjn.2017.287",

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T1 - Defining CT Perfusion Thresholds for Infarction in the Golden Hour and with Ultra-Early Reperfusion

AU - Najm, Mohamed

AU - Al-Ajlan, Fahad S.

AU - Boesen, Mari E.

AU - Hur, Lisa

AU - Kim, Chi Kyung

AU - Fainardi, Enrico

AU - Hill, Michael D.

AU - Demchuk, Andrew M.

AU - Goyal, Mayank

AU - Lee, Ting Y.

AU - Menon, Bijoy K.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - In this brief report, computed tomography perfusion (CTP) thresholds predicting follow-up infarction in patients presenting <3 hours from stroke onset and achieving ultra-early reperfusion (<45 minutes from CTP) are reported. CTP thresholds that predict follow-up infarction vary based on time to reperfusion: Tmax >20 to 23 seconds and cerebral blood flow <5 to 7 ml/min -1 /(100 g) -1 or relative cerebral blood flow <0.14 to 0.20 optimally predicted the final infarct. These thresholds are stricter than published thresholds.

AB - In this brief report, computed tomography perfusion (CTP) thresholds predicting follow-up infarction in patients presenting <3 hours from stroke onset and achieving ultra-early reperfusion (<45 minutes from CTP) are reported. CTP thresholds that predict follow-up infarction vary based on time to reperfusion: Tmax >20 to 23 seconds and cerebral blood flow <5 to 7 ml/min -1 /(100 g) -1 or relative cerebral blood flow <0.14 to 0.20 optimally predicted the final infarct. These thresholds are stricter than published thresholds.

KW - CT perfusion

KW - early reperfusion

KW - endovascular therapy

UR - https://www.scopus.com/pages/publications/85047195542

U2 - 10.1017/cjn.2017.287

DO - 10.1017/cjn.2017.287

M3 - Artículo

C2 - 29455683

AN - SCOPUS:85047195542

SN - 0317-1671

VL - 45

SP - 339

EP - 342

JO - Canadian Journal of Neurological Sciences

JF - Canadian Journal of Neurological Sciences

IS - 3

ER -

Defining CT Perfusion Thresholds for Infarction in the Golden Hour and with Ultra-Early Reperfusion

Abstract

Keywords

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