Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues

Silvana Duran-Ortiz; Vanessa Noboa; John J. Kopchick

doi:10.1016/j.ghir.2017.11.003

Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues

Silvana Duran-Ortiz
, Vanessa Noboa
, John J. Kopchick^*

^*Corresponding author for this work

Medicina

Ohio University
College of Arts and Sciences
Molecular and Cellular Biology Program
Ohio University

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

To elucidate whether a specific tissue is responsible for the beneficial health and longevity phenotype seen in growth hormone (GH) receptor (R) knockout (GHRKO) mice, the GHR gene was disrupted specifically in insulin sensitive tissues; namely, liver, adipose, and muscle. Furthermore, to investigate if the health- and life-span effects seen in the germline GHRKO mice were replicated when GH action was ablated after puberty; young, adult onset GHRKO mice were produced and characterized. In this review, we summarized the main findings derived from these mouse lines.

Original language	English
Pages (from-to)	3-7
Number of pages	5
Journal	Growth Hormone and IGF Research
Volume	38
DOIs	https://doi.org/10.1016/j.ghir.2017.11.003
State	Published - Feb 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adipose tissue
Growth hormone receptor
IGF-I
Liver
Muscle

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10.1016/j.ghir.2017.11.003

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title = "Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues",

abstract = "To elucidate whether a specific tissue is responsible for the beneficial health and longevity phenotype seen in growth hormone (GH) receptor (R) knockout (GHRKO) mice, the GHR gene was disrupted specifically in insulin sensitive tissues; namely, liver, adipose, and muscle. Furthermore, to investigate if the health- and life-span effects seen in the germline GHRKO mice were replicated when GH action was ablated after puberty; young, adult onset GHRKO mice were produced and characterized. In this review, we summarized the main findings derived from these mouse lines.",

keywords = "Adipose tissue, Growth hormone receptor, IGF-I, Liver, Muscle",

author = "Silvana Duran-Ortiz and Vanessa Noboa and Kopchick, \{John J.\}",

note = "Publisher Copyright: {\textcopyright} 2017",

year = "2018",

month = feb,

doi = "10.1016/j.ghir.2017.11.003",

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TY - JOUR

T1 - Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues

AU - Duran-Ortiz, Silvana

AU - Noboa, Vanessa

AU - Kopchick, John J.

PY - 2018/2

Y1 - 2018/2

N2 - To elucidate whether a specific tissue is responsible for the beneficial health and longevity phenotype seen in growth hormone (GH) receptor (R) knockout (GHRKO) mice, the GHR gene was disrupted specifically in insulin sensitive tissues; namely, liver, adipose, and muscle. Furthermore, to investigate if the health- and life-span effects seen in the germline GHRKO mice were replicated when GH action was ablated after puberty; young, adult onset GHRKO mice were produced and characterized. In this review, we summarized the main findings derived from these mouse lines.

AB - To elucidate whether a specific tissue is responsible for the beneficial health and longevity phenotype seen in growth hormone (GH) receptor (R) knockout (GHRKO) mice, the GHR gene was disrupted specifically in insulin sensitive tissues; namely, liver, adipose, and muscle. Furthermore, to investigate if the health- and life-span effects seen in the germline GHRKO mice were replicated when GH action was ablated after puberty; young, adult onset GHRKO mice were produced and characterized. In this review, we summarized the main findings derived from these mouse lines.

KW - Adipose tissue

KW - Growth hormone receptor

KW - IGF-I

KW - Liver

KW - Muscle

UR - https://www.scopus.com/pages/publications/85036566589

U2 - 10.1016/j.ghir.2017.11.003

DO - 10.1016/j.ghir.2017.11.003

M3 - Artículo

C2 - 29198419

AN - SCOPUS:85036566589

SN - 1096-6374

VL - 38

SP - 3

EP - 7

JO - Growth Hormone and IGF Research

JF - Growth Hormone and IGF Research

ER -

Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues

Abstract

UN SDGs

Keywords

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