Endogenous origin of Pseudomonas aeruginosa infecting hospitalized patients in Ecuador

Gabriela Vasco; Mishell Achig; Belén Prado-Vivar; Maritza Páez; Franklin Espinosa; Evelyn Espinoza; Danny Quinancela; Paul Cardenas; Gabriel Trueba

doi:10.1016/j.infpip.2023.100331

Endogenous origin of Pseudomonas aeruginosa infecting hospitalized patients in Ecuador

Gabriela Vasco^*
, Mishell Achig
, Belén Prado-Vivar
, Maritza Páez
, Franklin Espinosa
, Evelyn Espinoza
, Danny Quinancela
, Paul Cardenas
, Gabriel Trueba

^*Corresponding author for this work

Universidad Central del Ecuador
Walter and Eliza Hall Institute of Medical Research
University of Melbourne
MSP
Hospital “Padre Carollo Un Canto Para la Vida”

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Recent evidence suggests that Pseudomonas aeruginosa, a bacterium that has the ability to cause deadly infections in hospitalized patients, could originate in the patient's own flora. We employed the Oxford Nanopore platform to obtain whole genome sequences (WGS) from clinical and rectal screen P. aeruginosa strains belonging to 15 patients from two hospitals. Our study found evidence that clinical and rectal isolates were clonal, with some evidence suggesting that the infecting strain was present in the patient's intestine at the time of admission, ruling out hospital acquisition. The use of WGS analysis is crucial to detect alternative sources of P. aeruginosa to develop new preventive measures against these serious infections.

Original language	English
Article number	100331
Journal	Infection Prevention in Practice
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/j.infpip.2023.100331
State	Published - Mar 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute infection
Colonization
Nosocomial
Pseudomonas aeruginosa
Whole genome sequencing

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10.1016/j.infpip.2023.100331

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title = "Endogenous origin of Pseudomonas aeruginosa infecting hospitalized patients in Ecuador",

abstract = "Recent evidence suggests that Pseudomonas aeruginosa, a bacterium that has the ability to cause deadly infections in hospitalized patients, could originate in the patient's own flora. We employed the Oxford Nanopore platform to obtain whole genome sequences (WGS) from clinical and rectal screen P. aeruginosa strains belonging to 15 patients from two hospitals. Our study found evidence that clinical and rectal isolates were clonal, with some evidence suggesting that the infecting strain was present in the patient's intestine at the time of admission, ruling out hospital acquisition. The use of WGS analysis is crucial to detect alternative sources of P. aeruginosa to develop new preventive measures against these serious infections.",

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T1 - Endogenous origin of Pseudomonas aeruginosa infecting hospitalized patients in Ecuador

AU - Vasco, Gabriela

AU - Achig, Mishell

AU - Prado-Vivar, Belén

AU - Páez, Maritza

AU - Espinosa, Franklin

AU - Espinoza, Evelyn

AU - Quinancela, Danny

AU - Cardenas, Paul

AU - Trueba, Gabriel

PY - 2024/3

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N2 - Recent evidence suggests that Pseudomonas aeruginosa, a bacterium that has the ability to cause deadly infections in hospitalized patients, could originate in the patient's own flora. We employed the Oxford Nanopore platform to obtain whole genome sequences (WGS) from clinical and rectal screen P. aeruginosa strains belonging to 15 patients from two hospitals. Our study found evidence that clinical and rectal isolates were clonal, with some evidence suggesting that the infecting strain was present in the patient's intestine at the time of admission, ruling out hospital acquisition. The use of WGS analysis is crucial to detect alternative sources of P. aeruginosa to develop new preventive measures against these serious infections.

AB - Recent evidence suggests that Pseudomonas aeruginosa, a bacterium that has the ability to cause deadly infections in hospitalized patients, could originate in the patient's own flora. We employed the Oxford Nanopore platform to obtain whole genome sequences (WGS) from clinical and rectal screen P. aeruginosa strains belonging to 15 patients from two hospitals. Our study found evidence that clinical and rectal isolates were clonal, with some evidence suggesting that the infecting strain was present in the patient's intestine at the time of admission, ruling out hospital acquisition. The use of WGS analysis is crucial to detect alternative sources of P. aeruginosa to develop new preventive measures against these serious infections.

KW - Acute infection

KW - Colonization

KW - Nosocomial

KW - Pseudomonas aeruginosa

KW - Whole genome sequencing

UR - https://www.scopus.com/pages/publications/85181256838

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DO - 10.1016/j.infpip.2023.100331

M3 - Artículo

AN - SCOPUS:85181256838

SN - 2590-0889

VL - 6

JO - Infection Prevention in Practice

JF - Infection Prevention in Practice

IS - 1

M1 - 100331

ER -

Endogenous origin of Pseudomonas aeruginosa infecting hospitalized patients in Ecuador

Abstract

UN SDGs

Keywords

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