Facial morphometry of Ecuadorian patients with growth hormone receptor deficiency/Laron syndrome

G. B. Schaefer; A. L. Rosenbloom; J. Guevara-Aguirre; E. A. Campbell; F. Ullrich; K. Patil; J. L. Frias

doi:10.1136/jmg.31.8.635

Facial morphometry of Ecuadorian patients with growth hormone receptor deficiency/Laron syndrome

G. B. Schaefer^*
, A. L. Rosenbloom
, J. Guevara-Aguirre
, E. A. Campbell
, F. Ullrich
, K. Patil
, J. L. Frias

^*Corresponding author for this work

University of Nebraska Medical Center
University of Florida
Inst. Endocrinol.
Univ. of Nebraska Medical Center

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Facial morphometry using computerised image analysis was performed on patients with growth hormone receptor deficiency (Laron syndrome) from an inbred population of southern Ecuador. Morphometrics were compared for 49 patients, 70 unaffected relatives, and 14 unrelated persons. Patients with growth hormone receptor deficiency showed significant decreases in measures of vertical facial growth as compared to unaffected relatives and unrelated persons with short stature from other causes. This report validates and quantifies the clinical impression of foreshortened facies in growth hormone receptor deficiency.

Original language	English
Pages (from-to)	635-639
Number of pages	5
Journal	Journal of Medical Genetics
Volume	31
Issue number	8
DOIs	https://doi.org/10.1136/jmg.31.8.635
State	Published - Aug 1994
Externally published	Yes

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title = "Facial morphometry of Ecuadorian patients with growth hormone receptor deficiency/Laron syndrome",

abstract = "Facial morphometry using computerised image analysis was performed on patients with growth hormone receptor deficiency (Laron syndrome) from an inbred population of southern Ecuador. Morphometrics were compared for 49 patients, 70 unaffected relatives, and 14 unrelated persons. Patients with growth hormone receptor deficiency showed significant decreases in measures of vertical facial growth as compared to unaffected relatives and unrelated persons with short stature from other causes. This report validates and quantifies the clinical impression of foreshortened facies in growth hormone receptor deficiency.",

author = "Schaefer, \{G. B.\} and Rosenbloom, \{A. L.\} and J. Guevara-Aguirre and Campbell, \{E. A.\} and F. Ullrich and K. Patil and Frias, \{J. L.\}",

year = "1994",

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AU - Schaefer, G. B.

AU - Rosenbloom, A. L.

AU - Guevara-Aguirre, J.

AU - Campbell, E. A.

AU - Ullrich, F.

AU - Patil, K.

AU - Frias, J. L.

PY - 1994/8

Y1 - 1994/8

N2 - Facial morphometry using computerised image analysis was performed on patients with growth hormone receptor deficiency (Laron syndrome) from an inbred population of southern Ecuador. Morphometrics were compared for 49 patients, 70 unaffected relatives, and 14 unrelated persons. Patients with growth hormone receptor deficiency showed significant decreases in measures of vertical facial growth as compared to unaffected relatives and unrelated persons with short stature from other causes. This report validates and quantifies the clinical impression of foreshortened facies in growth hormone receptor deficiency.

AB - Facial morphometry using computerised image analysis was performed on patients with growth hormone receptor deficiency (Laron syndrome) from an inbred population of southern Ecuador. Morphometrics were compared for 49 patients, 70 unaffected relatives, and 14 unrelated persons. Patients with growth hormone receptor deficiency showed significant decreases in measures of vertical facial growth as compared to unaffected relatives and unrelated persons with short stature from other causes. This report validates and quantifies the clinical impression of foreshortened facies in growth hormone receptor deficiency.

UR - https://www.scopus.com/pages/publications/0027964342

U2 - 10.1136/jmg.31.8.635

DO - 10.1136/jmg.31.8.635

M3 - Artículo

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AN - SCOPUS:0027964342

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JF - Journal of Medical Genetics

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ER -

Facial morphometry of Ecuadorian patients with growth hormone receptor deficiency/Laron syndrome

Abstract

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