Graphene quantum dots decorated with imatinib for leukemia treatment

Daniele Mendes Felix; Luciana Magalhães Rebelo Alencar; Frederico Duarte de Menezes; Victor do Valle Pereira Midlej; Lorayne Aguiar; Sara Gemini Piperni; Jian Zhang; Yin Liu; Eduardo Ricci-Junior; Frank Alexis; Severino Alves Junior; Lin Zhu; Ralph Santos-Oliveira

doi:10.1016/j.jddst.2020.102117

Graphene quantum dots decorated with imatinib for leukemia treatment

Daniele Mendes Felix
, Luciana Magalhães Rebelo Alencar
, Frederico Duarte de Menezes
, Victor do Valle Pereira Midlej
, Lorayne Aguiar
, Sara Gemini Piperni
, Jian Zhang
, Yin Liu
, Eduardo Ricci-Junior
, Frank Alexis
, Severino Alves Junior
, Lin Zhu
, Ralph Santos-Oliveira^*

^*Corresponding author for this work

Comissão Nacional de Energia Nuclear
Federal University of Maranhão
Instituto Federal de Pernambuco
Fundação Oswaldo Cruz
Universidade Unigranrio Afya
Texas AandM University
Museu Nacional/UFRJ
Universidad Yachay Tech
Universidade Federal de Pernambuco
Universidade do Estado do Rio de Janeiro

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The use of graphene quantum dots as biomedical device and drug delivery system has been increasing. This nano-platform of pure carbon has showed unique properties and showed to be safe for human use. The imatinib is a molecule designed to specifically inhibit the tyrosine kinase, used for leukemia treatment. In this study, we successfully decorated the graphene quantum dots (GQDs@imatinb) by a carbodiimide crosslinking reaction. The GQDs@imatinb were characterized by FTIR and AFM. The nanoparticles' in vitro behaviors were evaluated by cellular trafficking (internalization) assay and cell viability and apoptosis assays in various cancer cell lines, including suspension (leukemia) cells and adherent cancer cells. The results showed that the incorporation of the imatinib on the surface of the graphene quantum dots did not change the nanoparticles’ morphology and properties. The GQDs@imatinb could be efficiently internalized and kill cancer cells via the induction of apoptosis. The data indicated that the prepared GQDs@imatinb might be a great drug nano-platform for cancer, particularly leukemia treatments.

Original language	English
Article number	102117
Journal	Journal of Drug Delivery Science and Technology
Volume	61
DOIs	https://doi.org/10.1016/j.jddst.2020.102117
State	Published - Feb 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biomedical device
Drug delivery
Graphene quantum dot
Nanoparticle
Smart material

Access to Document

10.1016/j.jddst.2020.102117

Cite this

Felix, D. M., Rebelo Alencar, L. M., Duarte de Menezes, F., Midlej, V. D. V. P., Aguiar, L., Gemini Piperni, S., Zhang, J., Liu, Y., Ricci-Junior, E., Alexis, F., Junior, S. A., Zhu, L., & Santos-Oliveira, R. (2021). Graphene quantum dots decorated with imatinib for leukemia treatment. Journal of Drug Delivery Science and Technology, 61, Article 102117. https://doi.org/10.1016/j.jddst.2020.102117

@article{e742aec74cbd449b9118636832aef332,

title = "Graphene quantum dots decorated with imatinib for leukemia treatment",

abstract = "The use of graphene quantum dots as biomedical device and drug delivery system has been increasing. This nano-platform of pure carbon has showed unique properties and showed to be safe for human use. The imatinib is a molecule designed to specifically inhibit the tyrosine kinase, used for leukemia treatment. In this study, we successfully decorated the graphene quantum dots (GQDs@imatinb) by a carbodiimide crosslinking reaction. The GQDs@imatinb were characterized by FTIR and AFM. The nanoparticles' in vitro behaviors were evaluated by cellular trafficking (internalization) assay and cell viability and apoptosis assays in various cancer cell lines, including suspension (leukemia) cells and adherent cancer cells. The results showed that the incorporation of the imatinib on the surface of the graphene quantum dots did not change the nanoparticles{\textquoteright} morphology and properties. The GQDs@imatinb could be efficiently internalized and kill cancer cells via the induction of apoptosis. The data indicated that the prepared GQDs@imatinb might be a great drug nano-platform for cancer, particularly leukemia treatments.",

keywords = "Biomedical device, Drug delivery, Graphene quantum dot, Nanoparticle, Smart material",

author = "Felix, \{Daniele Mendes\} and \{Rebelo Alencar\}, \{Luciana Magalh{\~a}es\} and \{Duarte de Menezes\}, Frederico and Midlej, \{Victor do Valle Pereira\} and Lorayne Aguiar and \{Gemini Piperni\}, Sara and Jian Zhang and Yin Liu and Eduardo Ricci-Junior and Frank Alexis and Junior, \{Severino Alves\} and Lin Zhu and Ralph Santos-Oliveira",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2021",

month = feb,

doi = "10.1016/j.jddst.2020.102117",

language = "Ingl{\'e}s",

volume = "61",

journal = "Journal of Drug Delivery Science and Technology",

issn = "1773-2247",

publisher = "Editions de Sante",

}

Felix, DM, Rebelo Alencar, LM, Duarte de Menezes, F, Midlej, VDVP, Aguiar, L, Gemini Piperni, S, Zhang, J, Liu, Y, Ricci-Junior, E, Alexis, F, Junior, SA, Zhu, L & Santos-Oliveira, R 2021, 'Graphene quantum dots decorated with imatinib for leukemia treatment', Journal of Drug Delivery Science and Technology, vol. 61, 102117. https://doi.org/10.1016/j.jddst.2020.102117

TY - JOUR

T1 - Graphene quantum dots decorated with imatinib for leukemia treatment

AU - Felix, Daniele Mendes

AU - Rebelo Alencar, Luciana Magalhães

AU - Duarte de Menezes, Frederico

AU - Midlej, Victor do Valle Pereira

AU - Aguiar, Lorayne

AU - Gemini Piperni, Sara

AU - Zhang, Jian

AU - Liu, Yin

AU - Ricci-Junior, Eduardo

AU - Alexis, Frank

AU - Junior, Severino Alves

AU - Zhu, Lin

AU - Santos-Oliveira, Ralph

PY - 2021/2

Y1 - 2021/2

N2 - The use of graphene quantum dots as biomedical device and drug delivery system has been increasing. This nano-platform of pure carbon has showed unique properties and showed to be safe for human use. The imatinib is a molecule designed to specifically inhibit the tyrosine kinase, used for leukemia treatment. In this study, we successfully decorated the graphene quantum dots (GQDs@imatinb) by a carbodiimide crosslinking reaction. The GQDs@imatinb were characterized by FTIR and AFM. The nanoparticles' in vitro behaviors were evaluated by cellular trafficking (internalization) assay and cell viability and apoptosis assays in various cancer cell lines, including suspension (leukemia) cells and adherent cancer cells. The results showed that the incorporation of the imatinib on the surface of the graphene quantum dots did not change the nanoparticles’ morphology and properties. The GQDs@imatinb could be efficiently internalized and kill cancer cells via the induction of apoptosis. The data indicated that the prepared GQDs@imatinb might be a great drug nano-platform for cancer, particularly leukemia treatments.

AB - The use of graphene quantum dots as biomedical device and drug delivery system has been increasing. This nano-platform of pure carbon has showed unique properties and showed to be safe for human use. The imatinib is a molecule designed to specifically inhibit the tyrosine kinase, used for leukemia treatment. In this study, we successfully decorated the graphene quantum dots (GQDs@imatinb) by a carbodiimide crosslinking reaction. The GQDs@imatinb were characterized by FTIR and AFM. The nanoparticles' in vitro behaviors were evaluated by cellular trafficking (internalization) assay and cell viability and apoptosis assays in various cancer cell lines, including suspension (leukemia) cells and adherent cancer cells. The results showed that the incorporation of the imatinib on the surface of the graphene quantum dots did not change the nanoparticles’ morphology and properties. The GQDs@imatinb could be efficiently internalized and kill cancer cells via the induction of apoptosis. The data indicated that the prepared GQDs@imatinb might be a great drug nano-platform for cancer, particularly leukemia treatments.

KW - Biomedical device

KW - Drug delivery

KW - Graphene quantum dot

KW - Nanoparticle

KW - Smart material

UR - https://www.scopus.com/pages/publications/85092260960

U2 - 10.1016/j.jddst.2020.102117

DO - 10.1016/j.jddst.2020.102117

M3 - Artículo

AN - SCOPUS:85092260960

SN - 1773-2247

VL - 61

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

M1 - 102117

ER -

Graphene quantum dots decorated with imatinib for leukemia treatment

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this