Growth in growth hormone insensitivity

Arlan L. Rosenbloom; Jaime Guevara-Aguirre; Ron G. Rosenfeld; Brad H. Pollock

doi:10.1016/1043-2760(94)P3205-L

Growth in growth hormone insensitivity

Arlan L. Rosenbloom^*
, Jaime Guevara-Aguirre
, Ron G. Rosenfeld
, Brad H. Pollock

^*Corresponding author for this work

University of Florida
Institute of Endocrinology, Metabolism and Reproduction
University of Oregon

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

Primary GH insensitivity due to GH receptor deficiency (GHRD) provides a model for studying the discrete effects of severe IGF-I deficiency on growth and body composition. Growth failure in utero is doubtful, but postpartum growth proceeds at rates that result in adult statures 4-12 standard deviations (SDs) below the normal mean. Wide variability in statural effect, even in a genetically homogeneous population, is partly explained by correlation of SD score with biochemical measures of GH effect (IGF-I, IGF-II, and IGFBP-3). Growth and changes in body composition (decreased fat/lean) in patients with GHRD in response to exogenous IGF-I indicate that direct local effects of GH are not necessary for these responses.

Original language	English
Pages (from-to)	296-303
Number of pages	8
Journal	Trends in Endocrinology and Metabolism
Volume	5
Issue number	7
DOIs	https://doi.org/10.1016/1043-2760(94)P3205-L
State	Published - Sep 1994
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/1043-2760(94)P3205-L

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title = "Growth in growth hormone insensitivity",

abstract = "Primary GH insensitivity due to GH receptor deficiency (GHRD) provides a model for studying the discrete effects of severe IGF-I deficiency on growth and body composition. Growth failure in utero is doubtful, but postpartum growth proceeds at rates that result in adult statures 4-12 standard deviations (SDs) below the normal mean. Wide variability in statural effect, even in a genetically homogeneous population, is partly explained by correlation of SD score with biochemical measures of GH effect (IGF-I, IGF-II, and IGFBP-3). Growth and changes in body composition (decreased fat/lean) in patients with GHRD in response to exogenous IGF-I indicate that direct local effects of GH are not necessary for these responses.",

author = "Rosenbloom, \{Arlan L.\} and Jaime Guevara-Aguirre and Rosenfeld, \{Ron G.\} and Pollock, \{Brad H.\}",

year = "1994",

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doi = "10.1016/1043-2760(94)P3205-L",

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T1 - Growth in growth hormone insensitivity

AU - Rosenbloom, Arlan L.

AU - Guevara-Aguirre, Jaime

AU - Rosenfeld, Ron G.

AU - Pollock, Brad H.

PY - 1994/9

Y1 - 1994/9

N2 - Primary GH insensitivity due to GH receptor deficiency (GHRD) provides a model for studying the discrete effects of severe IGF-I deficiency on growth and body composition. Growth failure in utero is doubtful, but postpartum growth proceeds at rates that result in adult statures 4-12 standard deviations (SDs) below the normal mean. Wide variability in statural effect, even in a genetically homogeneous population, is partly explained by correlation of SD score with biochemical measures of GH effect (IGF-I, IGF-II, and IGFBP-3). Growth and changes in body composition (decreased fat/lean) in patients with GHRD in response to exogenous IGF-I indicate that direct local effects of GH are not necessary for these responses.

AB - Primary GH insensitivity due to GH receptor deficiency (GHRD) provides a model for studying the discrete effects of severe IGF-I deficiency on growth and body composition. Growth failure in utero is doubtful, but postpartum growth proceeds at rates that result in adult statures 4-12 standard deviations (SDs) below the normal mean. Wide variability in statural effect, even in a genetically homogeneous population, is partly explained by correlation of SD score with biochemical measures of GH effect (IGF-I, IGF-II, and IGFBP-3). Growth and changes in body composition (decreased fat/lean) in patients with GHRD in response to exogenous IGF-I indicate that direct local effects of GH are not necessary for these responses.

UR - https://www.scopus.com/pages/publications/0028151599

U2 - 10.1016/1043-2760(94)P3205-L

DO - 10.1016/1043-2760(94)P3205-L

M3 - Artículo de revisión

AN - SCOPUS:0028151599

SN - 1043-2760

VL - 5

SP - 296

EP - 303

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 7

ER -

Growth in growth hormone insensitivity

Abstract

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