Heterogeneity of HPV genotypes in oropharyngeal condyloma accuminatum: Case report from Ecuador

Acuminated condyloma (AC), or venereal wart, is a viral infection caused by the human papillomavirus (HPV), primarily transmitted through sexual contact. Adolescents and young adults are the most vulnerable groups. Its presentation in the oral cavity is atypical, as is the involvement of HPV genotypes other than HPV-6/11/16/18. This report describes an unusual case of oropharyngeal condyloma in a young adult woman with dyslipidaemia and vitamin D deficiency, which exhibited co-infection with low-risk (HPV-6, 11) and high-risk oncogenic genotypes (HPV-59, 82). The latter two genotypes have not been reported in oral or oropharyngeal AC cases so far. Diagnosis was based on clinical and pathological findings, with a favourable prognosis despite the lesion's location. While AC diagnosis is primarily clinical, histopathological analysis is crucial for distinguishing it from other HPV-related oral conditions. Genotyping, though not essential for diagnosis, has epidemiological relevance in guiding vaccination strategies.