Horizontal mitochondrial transfer in cancer biology: Potential clinical relevance

Michael V. Berridge; Renata Zobalova; Stepana Boukalova; Andrés Caicedo; Stuart A. Rushworth; Jiri Neuzil

doi:10.1016/j.ccell.2025.03.002

Horizontal mitochondrial transfer in cancer biology: Potential clinical relevance

Michael V. Berridge^*
, Renata Zobalova
, Stepana Boukalova
, Andrés Caicedo
, Stuart A. Rushworth
, Jiri Neuzil^*

^*Corresponding author for this work

Malaghan Institute of Medical Research
Institute of Biotechnology of the Academy of Sciences of the Czech Republic
Mito-Act Research Consortium
University of East Anglia
Griffith University
Charles University

Research output: Contribution to journal › Comment/debate

19 Scopus citations

Abstract

Recent research highlights horizontal mitochondrial transfer as a key biological phenomenon linked to cancer onset and progression. The transfer of mitochondria and their genomes between cancer and non-cancer cells shifts our understanding of intercellular gene trafficking, increasing the metabolic fitness of cancer cells and modulating antitumor immune responses. This process not only facilitates tumor progression but also presents potential therapeutic opportunities.

Original language	English
Pages (from-to)	803-807
Number of pages	5
Journal	Cancer Cell
Volume	43
Issue number	5
DOIs	https://doi.org/10.1016/j.ccell.2025.03.002
State	Published - 12 May 2025

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SDG 3 Good Health and Well-being

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10.1016/j.ccell.2025.03.002

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title = "Horizontal mitochondrial transfer in cancer biology: Potential clinical relevance",

abstract = "Recent research highlights horizontal mitochondrial transfer as a key biological phenomenon linked to cancer onset and progression. The transfer of mitochondria and their genomes between cancer and non-cancer cells shifts our understanding of intercellular gene trafficking, increasing the metabolic fitness of cancer cells and modulating antitumor immune responses. This process not only facilitates tumor progression but also presents potential therapeutic opportunities.",

author = "Berridge, \{Michael V.\} and Renata Zobalova and Stepana Boukalova and Andr{\'e}s Caicedo and Rushworth, \{Stuart A.\} and Jiri Neuzil",

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T1 - Horizontal mitochondrial transfer in cancer biology

T2 - Potential clinical relevance

AU - Berridge, Michael V.

AU - Zobalova, Renata

AU - Boukalova, Stepana

AU - Caicedo, Andrés

AU - Rushworth, Stuart A.

AU - Neuzil, Jiri

PY - 2025/5/12

Y1 - 2025/5/12

N2 - Recent research highlights horizontal mitochondrial transfer as a key biological phenomenon linked to cancer onset and progression. The transfer of mitochondria and their genomes between cancer and non-cancer cells shifts our understanding of intercellular gene trafficking, increasing the metabolic fitness of cancer cells and modulating antitumor immune responses. This process not only facilitates tumor progression but also presents potential therapeutic opportunities.

AB - Recent research highlights horizontal mitochondrial transfer as a key biological phenomenon linked to cancer onset and progression. The transfer of mitochondria and their genomes between cancer and non-cancer cells shifts our understanding of intercellular gene trafficking, increasing the metabolic fitness of cancer cells and modulating antitumor immune responses. This process not only facilitates tumor progression but also presents potential therapeutic opportunities.

UR - https://www.scopus.com/pages/publications/105000676829

U2 - 10.1016/j.ccell.2025.03.002

DO - 10.1016/j.ccell.2025.03.002

M3 - Comentario/Debate

AN - SCOPUS:105000676829

SN - 1535-6108

VL - 43

SP - 803

EP - 807

JO - Cancer Cell

JF - Cancer Cell

IS - 5

ER -

Horizontal mitochondrial transfer in cancer biology: Potential clinical relevance

Abstract

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