La enzima tirosinasa: 2. Inhibidores de origen natural y sintético

Gerardo M. Casañola-Martín; Yovani Marrero-Ponce; Huong Le-Thi-Thu; Mahmud Tareq Hassan Khan; Francisco Torrens; Antonio Rescigno; Concepción Abad

La enzima tirosinasa: 2. Inhibidores de origen natural y sintético

Translated title of the contribution: Tyrosinase enzyme: 2. Inhibitors from natural and synthetic origins

Gerardo M. Casañola-Martín
, Yovani Marrero-Ponce
, Huong Le-Thi-Thu
, Mahmud Tareq Hassan Khan
, Francisco Torrens
, Antonio Rescigno
, Concepción Abad

Ministerio de Ciencia Tecnología y Medio Ambiente (CITMA)
Universidad Central Marta Abreu de Las Villas
Universitat de València
University of Illinois at Chicago
Dip. Scienze e Tecnologie Biomediche

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

In this work there are tackled in a general way the tyrosinase inhibitor compounds, the limiting enzyme and the fundamental key for the skin pigmentation control in human beings. The main characteristics of the depigmenting agents used in the medical practice are depicted. Besides, the compounds studied until nowadays are showed, which are grouped taking into account its origin: naturals, synthetics and drug with other therapeutic uses, discovered with inhibitory activity against the enzyme. Finally the last advances in the cheminformatic and molecular modeling field related with the study of the enzyme and its inhibitors are discussed.

Translated title of the contribution	Tyrosinase enzyme: 2. Inhibitors from natural and synthetic origins
Original language	Spanish
Pages (from-to)	270-276
Number of pages	7
Journal	Afinidad
Volume	70
Issue number	564
State	Published - 2013
Externally published	Yes

Cite this

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title = "La enzima tirosinasa: 2. Inhibidores de origen natural y sint{\'e}tico",

abstract = "In this work there are tackled in a general way the tyrosinase inhibitor compounds, the limiting enzyme and the fundamental key for the skin pigmentation control in human beings. The main characteristics of the depigmenting agents used in the medical practice are depicted. Besides, the compounds studied until nowadays are showed, which are grouped taking into account its origin: naturals, synthetics and drug with other therapeutic uses, discovered with inhibitory activity against the enzyme. Finally the last advances in the cheminformatic and molecular modeling field related with the study of the enzyme and its inhibitors are discussed.",

keywords = "Drugs, Natural products, Synthetic compounds, Tyrosinase inhibitors",

author = "Casa{\~n}ola-Mart{\'i}n, \{Gerardo M.\} and Yovani Marrero-Ponce and Huong Le-Thi-Thu and Khan, \{Mahmud Tareq Hassan\} and Francisco Torrens and Antonio Rescigno and Concepci{\'o}n Abad",

year = "2013",

language = "Espa{\~n}ol",

volume = "70",

pages = "270--276",

journal = "Afinidad",

issn = "0001-9704",

publisher = "Asociacion de Quimicos del Instituto Quimico de Sarria",

number = "564",

}

TY - JOUR

T1 - La enzima tirosinasa

T2 - 2. Inhibidores de origen natural y sintético

AU - Casañola-Martín, Gerardo M.

AU - Marrero-Ponce, Yovani

AU - Le-Thi-Thu, Huong

AU - Khan, Mahmud Tareq Hassan

AU - Torrens, Francisco

AU - Rescigno, Antonio

AU - Abad, Concepción

PY - 2013

Y1 - 2013

N2 - In this work there are tackled in a general way the tyrosinase inhibitor compounds, the limiting enzyme and the fundamental key for the skin pigmentation control in human beings. The main characteristics of the depigmenting agents used in the medical practice are depicted. Besides, the compounds studied until nowadays are showed, which are grouped taking into account its origin: naturals, synthetics and drug with other therapeutic uses, discovered with inhibitory activity against the enzyme. Finally the last advances in the cheminformatic and molecular modeling field related with the study of the enzyme and its inhibitors are discussed.

AB - In this work there are tackled in a general way the tyrosinase inhibitor compounds, the limiting enzyme and the fundamental key for the skin pigmentation control in human beings. The main characteristics of the depigmenting agents used in the medical practice are depicted. Besides, the compounds studied until nowadays are showed, which are grouped taking into account its origin: naturals, synthetics and drug with other therapeutic uses, discovered with inhibitory activity against the enzyme. Finally the last advances in the cheminformatic and molecular modeling field related with the study of the enzyme and its inhibitors are discussed.

KW - Drugs

KW - Natural products

KW - Synthetic compounds

KW - Tyrosinase inhibitors

UR - https://www.scopus.com/pages/publications/84893616877

M3 - Artículo

AN - SCOPUS:84893616877

SN - 0001-9704

VL - 70

SP - 270

EP - 276

JO - Afinidad

JF - Afinidad

IS - 564

ER -

La enzima tirosinasa: 2. Inhibidores de origen natural y sintético

Abstract

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