TY - JOUR
T1 - Latin American Trans-ancestry INitiative for OCD genomics (LATINO)
T2 - Study protocol
AU - Latin American Trans-ancestry INitiative for OCD genomics
AU - Brazilian Obsessive-Compulsive Spectrum Disorder Working Group
AU - Crowley, James J.
AU - Cappi, Carolina
AU - Ochoa-Panaifo, Marcos E.
AU - Frederick, Renee M.
AU - Kook, Minjee
AU - Wiese, Andrew D.
AU - Rancourt, Diana
AU - Atkinson, Elizabeth G.
AU - Giusti-Rodriguez, Paola
AU - Anderberg, Jacey L.
AU - Abramowitz, Jonathan S.
AU - Adorno, Victor R.
AU - Aguirre, Cinthia
AU - Alves, Gilberto S.
AU - Alves, Gustavo S.
AU - Ancalade, Na Eshia
AU - Anderberg, Jacey L.
AU - Arellano Espinosa, Alejandro A.
AU - Arnold, Paul D.
AU - Atkinson, Elizabeth G.
AU - Ayton, Daphne M.
AU - Barbosa, Izabela G.
AU - Castano, Laura Marcela Barón
AU - Barrera, Cynthia N.
AU - Berardo, María Celeste
AU - Berrones, Dayan
AU - Best, John R.
AU - Bigdeli, Tim B.
AU - Borda, Tania
AU - Burton, Christie L.
AU - Buxbaum, Joseph D.
AU - Callahan, Jennifer L.
AU - Cappi, Carolina
AU - Carneiro, Maria Cecília B.
AU - Cepeda, Sandra L.
AU - Chazelle, Evelyn
AU - Chire, Jessica M.
AU - Munoz, Macarena Churruca
AU - Quiroz, Pamela Claisse
AU - Cobite, Journa
AU - Comer, Jonathan S.
AU - Costa, Daniel L.
AU - Crosbie, Jennifer
AU - Crowley, James J.
AU - Cruz, Victor O.
AU - Dager, Guillermo
AU - Daza, Luisa F.
AU - de la Rosa-Gómez, Anabel
AU - del Río, Daniela
AU - Paz y Mino, Mariel
N1 - Publisher Copyright:
© 2023 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals LLC.
PY - 2024/6
Y1 - 2024/6
N2 - Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.
AB - Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.
KW - GWAS
KW - Latin American
KW - OCD
KW - genetic
KW - genomic
KW - obsessive-compulsive disorder
UR - https://www.scopus.com/pages/publications/85176913852
U2 - 10.1002/ajmg.b.32962
DO - 10.1002/ajmg.b.32962
M3 - Artículo
C2 - 37946624
AN - SCOPUS:85176913852
SN - 1552-4841
VL - 195
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
IS - 4
M1 - e32962
ER -
SDG 3 Good Health and Well-being