Longitudinal Proteomic Profiling of Cognition across an Aerobic Exercise Intervention

Alison M.H. Donald; Luiz G.N. de Almeida; Mohamed Ziad Dabaja; Isabella Orchard; Kaia Ybema; Veronica Tsegai; Victoria Armstrong; Sophie Smith; Daniel Young; Richard Stewart Longman; Amanda V. Tyndall; Jean M. Rawling; Michael D. Hill; Willis H. Tsai; Ejaife Agbani; Marc J. Poulin; Antoine Dufour

doi:10.1002/ana.27210

Longitudinal Proteomic Profiling of Cognition across an Aerobic Exercise Intervention

Alison M.H. Donald
, Luiz G.N. de Almeida
, Mohamed Ziad Dabaja
, Isabella Orchard
, Kaia Ybema
, Veronica Tsegai
, Victoria Armstrong
, Sophie Smith
, Daniel Young
, Richard Stewart Longman
, Amanda V. Tyndall
, Jean M. Rawling
, Michael D. Hill
, Willis H. Tsai
, Ejaife Agbani
, Marc J. Poulin^*
, Antoine Dufour^*

^*Corresponding author for this work

University of Calgary
Brenda Strafford Foundation

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The physiological basis of cognitive decline remains largely uncharacterized. We identified a protein panel signature, in living humans, that correlates to improvement in neurocognition over a period of 5 years. Our signature is composed of complement proteins, coagulation cascade, and extracellular matrix regulators. In our cohort, SERPINF1 is associated with greater maximal oxygen uptake after an aerobic exercise intervention. Sleep quality is also a key factor in relation to inter-alpha-trypsin inhibitor heavy chain H2, which was associated with greater sleep efficiency. Additionally, we validate that the coagulation profile of decliners’ plasma contains procoagulant agonists, leading to greater platelet activation. ANN NEUROL 2025;97:1007–1018.

Original language	English
Pages (from-to)	1007-1018
Number of pages	12
Journal	Annals of Neurology
Volume	97
Issue number	5
DOIs	https://doi.org/10.1002/ana.27210
State	Published - May 2025
Externally published	Yes

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Donald, A. M. H., de Almeida, L. G. N., Dabaja, M. Z., Orchard, I., Ybema, K., Tsegai, V., Armstrong, V., Smith, S., Young, D., Longman, R. S., Tyndall, A. V., Rawling, J. M., Hill, M. D., Tsai, W. H., Agbani, E., Poulin, M. J., & Dufour, A. (2025). Longitudinal Proteomic Profiling of Cognition across an Aerobic Exercise Intervention. Annals of Neurology, 97(5), 1007-1018. https://doi.org/10.1002/ana.27210

@article{c0f79b3be1384113b998f8fa343a6e39,

title = "Longitudinal Proteomic Profiling of Cognition across an Aerobic Exercise Intervention",

abstract = "The physiological basis of cognitive decline remains largely uncharacterized. We identified a protein panel signature, in living humans, that correlates to improvement in neurocognition over a period of 5 years. Our signature is composed of complement proteins, coagulation cascade, and extracellular matrix regulators. In our cohort, SERPINF1 is associated with greater maximal oxygen uptake after an aerobic exercise intervention. Sleep quality is also a key factor in relation to inter-alpha-trypsin inhibitor heavy chain H2, which was associated with greater sleep efficiency. Additionally, we validate that the coagulation profile of decliners{\textquoteright} plasma contains procoagulant agonists, leading to greater platelet activation. ANN NEUROL 2025;97:1007{\textendash}1018.",

author = "Donald, \{Alison M.H.\} and \{de Almeida\}, \{Luiz G.N.\} and Dabaja, \{Mohamed Ziad\} and Isabella Orchard and Kaia Ybema and Veronica Tsegai and Victoria Armstrong and Sophie Smith and Daniel Young and Longman, \{Richard Stewart\} and Tyndall, \{Amanda V.\} and Rawling, \{Jean M.\} and Hill, \{Michael D.\} and Tsai, \{Willis H.\} and Ejaife Agbani and Poulin, \{Marc J.\} and Antoine Dufour",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.",

year = "2025",

month = may,

doi = "10.1002/ana.27210",

language = "Ingl{\'e}s",

volume = "97",

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Donald, AMH, de Almeida, LGN, Dabaja, MZ, Orchard, I, Ybema, K, Tsegai, V, Armstrong, V, Smith, S, Young, D, Longman, RS, Tyndall, AV, Rawling, JM, Hill, MD, Tsai, WH, Agbani, E, Poulin, MJ & Dufour, A 2025, 'Longitudinal Proteomic Profiling of Cognition across an Aerobic Exercise Intervention', Annals of Neurology, vol. 97, no. 5, pp. 1007-1018. https://doi.org/10.1002/ana.27210

TY - JOUR

T1 - Longitudinal Proteomic Profiling of Cognition across an Aerobic Exercise Intervention

AU - Donald, Alison M.H.

AU - de Almeida, Luiz G.N.

AU - Dabaja, Mohamed Ziad

AU - Orchard, Isabella

AU - Ybema, Kaia

AU - Tsegai, Veronica

AU - Armstrong, Victoria

AU - Smith, Sophie

AU - Young, Daniel

AU - Longman, Richard Stewart

AU - Tyndall, Amanda V.

AU - Rawling, Jean M.

AU - Hill, Michael D.

AU - Tsai, Willis H.

AU - Agbani, Ejaife

AU - Poulin, Marc J.

AU - Dufour, Antoine

PY - 2025/5

Y1 - 2025/5

N2 - The physiological basis of cognitive decline remains largely uncharacterized. We identified a protein panel signature, in living humans, that correlates to improvement in neurocognition over a period of 5 years. Our signature is composed of complement proteins, coagulation cascade, and extracellular matrix regulators. In our cohort, SERPINF1 is associated with greater maximal oxygen uptake after an aerobic exercise intervention. Sleep quality is also a key factor in relation to inter-alpha-trypsin inhibitor heavy chain H2, which was associated with greater sleep efficiency. Additionally, we validate that the coagulation profile of decliners’ plasma contains procoagulant agonists, leading to greater platelet activation. ANN NEUROL 2025;97:1007–1018.

AB - The physiological basis of cognitive decline remains largely uncharacterized. We identified a protein panel signature, in living humans, that correlates to improvement in neurocognition over a period of 5 years. Our signature is composed of complement proteins, coagulation cascade, and extracellular matrix regulators. In our cohort, SERPINF1 is associated with greater maximal oxygen uptake after an aerobic exercise intervention. Sleep quality is also a key factor in relation to inter-alpha-trypsin inhibitor heavy chain H2, which was associated with greater sleep efficiency. Additionally, we validate that the coagulation profile of decliners’ plasma contains procoagulant agonists, leading to greater platelet activation. ANN NEUROL 2025;97:1007–1018.

UR - https://www.scopus.com/pages/publications/85218805654

U2 - 10.1002/ana.27210

DO - 10.1002/ana.27210

M3 - Artículo

C2 - 40013367

AN - SCOPUS:85218805654

SN - 0364-5134

VL - 97

SP - 1007

EP - 1018

JO - Annals of Neurology

JF - Annals of Neurology

IS - 5

ER -

Longitudinal Proteomic Profiling of Cognition across an Aerobic Exercise Intervention

Abstract

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