TY - JOUR
T1 - Management of transfusional iron overload in Latin America
T2 - Current outlook and expert panel recommendations
AU - Araújo, Aderson
AU - Drelichman, Guillermo
AU - Cançado, Rodolfo D.
AU - Watman, Nora
AU - Magalhães, Silvia M.M.
AU - Duhalde, Mauricio
AU - Marfil, Javier
AU - Feliú, Aurora
AU - Clementina, Landolfi
AU - Ballesteros, Adriana Linares
AU - di Stefano, Marco
AU - Angulo, Ivan
AU - Fattori, André
AU - Figueiredo, Stella
AU - Friedrich, João
AU - Pereira, Fabrício
AU - Peña, Jorge
AU - Barrero, Alberto
AU - Guerrero, Susan
AU - Gutiérrez-Espíndola, Guillermo
AU - Rojas, Victor Salinas
AU - Soto, Janet
AU - Boyd, Jaime
AU - Joly, Rafael
AU - Sergio, Murillo
AU - de Soyano, Aixa Müller
AU - Pérez-Bández, Olimpia
AU - Plumacher, Zaída
PY - 2009
Y1 - 2009
N2 - The results of a meeting of physicians convening in Latin America to develop expert opinions on the diagnosis, monitoring and treatment of iron overload are as follows. An accurate diagnosis can be obtained by neonatal screening for haemoglobinopathies, especially sickle cell disease and the thalassaemias. Disease-specific registries are needed to demonstrate the extent of the problem to health authorities. Disparities in the quantity and quality of blood products must be addressed, and uniform transfusion guidelines are necessary. Serum ferritin level is a feasible marker for iron overload in the region, while magnetic resonance imaging assessment can improve the diagnosis and monitoring of cardiac and liver iron content. Medical specialists, including radiologists, pathologists and others, and health authorities, can help to implement these methods and provide adequate resources. The recently available oral deferasirox can be used to conveniently administer iron chelation to transfusional iron-overloaded patients.
AB - The results of a meeting of physicians convening in Latin America to develop expert opinions on the diagnosis, monitoring and treatment of iron overload are as follows. An accurate diagnosis can be obtained by neonatal screening for haemoglobinopathies, especially sickle cell disease and the thalassaemias. Disease-specific registries are needed to demonstrate the extent of the problem to health authorities. Disparities in the quantity and quality of blood products must be addressed, and uniform transfusion guidelines are necessary. Serum ferritin level is a feasible marker for iron overload in the region, while magnetic resonance imaging assessment can improve the diagnosis and monitoring of cardiac and liver iron content. Medical specialists, including radiologists, pathologists and others, and health authorities, can help to implement these methods and provide adequate resources. The recently available oral deferasirox can be used to conveniently administer iron chelation to transfusional iron-overloaded patients.
KW - Blood transfusions
KW - Haemosiderosis
KW - Iron chelators
KW - Iron overload
UR - https://www.scopus.com/pages/publications/64949196097
U2 - 10.1179/102453309X385179
DO - 10.1179/102453309X385179
M3 - Artículo
C2 - 19154661
AN - SCOPUS:64949196097
SN - 1024-5332
VL - 14
SP - 22
EP - 32
JO - Hematology
JF - Hematology
IS - 1
ER -