Multilayered polymer-coated carbon nanotubes to deliver dasatinib

Thomas L. Moore; Stuart W. Grimes; Robert L. Lewis; Frank Alexis

doi:10.1021/mp400448w

Multilayered polymer-coated carbon nanotubes to deliver dasatinib

Thomas L. Moore
, Stuart W. Grimes
, Robert L. Lewis
, Frank Alexis^*

^*Corresponding author for this work

Clemson University College of Engineering, Computing and Applied Sciences

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Multilayered, multifunctional polymer coatings were grafted onto carbon nanotubes (CNTs) using a one-pot, ring-opening polymerization in order to control the release kinetic and therapeutic efficacy of dasatinib. Biocompatible, biodegradable multilayered coatings composed of poly(glycolide) (PGA) and poly(lactide) (PLA) were polymerized directly onto hydroxyl-functionalized CNT surfaces. Sequential addition of monomers into the reaction vessel enabled multilayered coatings of PLA-PGA or PGA-PLA. Poly(ethylene glycol) capped the polymer chain ends, resulting in a multifunctional amphiphilic coating. Multilayer polymer coatings on CNTs enabled control of the anticancer drug dasatinib's release kinetics and enhanced the in vitro therapeutic efficacy against U-87 glioblastoma compared to monolayer polymer coatings.

Original language	English
Pages (from-to)	276-282
Number of pages	7
Journal	Molecular Pharmaceutics
Volume	11
Issue number	1
DOIs	https://doi.org/10.1021/mp400448w
State	Published - 6 Jan 2014
Externally published	Yes

Keywords

carbon nanotube
encapsulation
multilayered polymer coatings
synthesis

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AB - Multilayered, multifunctional polymer coatings were grafted onto carbon nanotubes (CNTs) using a one-pot, ring-opening polymerization in order to control the release kinetic and therapeutic efficacy of dasatinib. Biocompatible, biodegradable multilayered coatings composed of poly(glycolide) (PGA) and poly(lactide) (PLA) were polymerized directly onto hydroxyl-functionalized CNT surfaces. Sequential addition of monomers into the reaction vessel enabled multilayered coatings of PLA-PGA or PGA-PLA. Poly(ethylene glycol) capped the polymer chain ends, resulting in a multifunctional amphiphilic coating. Multilayer polymer coatings on CNTs enabled control of the anticancer drug dasatinib's release kinetics and enhanced the in vitro therapeutic efficacy against U-87 glioblastoma compared to monolayer polymer coatings.

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KW - multilayered polymer coatings

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Multilayered polymer-coated carbon nanotubes to deliver dasatinib

Abstract

Keywords

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