Multiplex peptide nucleic acid fluorescence in situ hybridization (PNA-FISH) for diagnosis of bacterial vaginosis

Antonio Machado, Nuno Cerca

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations

Abstract

Fluorescence in situ hybridization (FISH) is a molecular method used to identify and quantify microorganisms in a wide range of samples. This technique combines the simplicity of microscopic observation and the specificity of DNA/rRNA hybridization, allowing detection of selected bacterial species and morphologic visualization. Here, we describe a quantitative molecular diagnosis of bacterial vaginosis, based on the classical Nugent score. Our probes are able to differentiate Lactobacillus spp. and Gardnerella vaginalis from the other undefined bacterial species considered in the Nugent score.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages209-219
Number of pages11
DOIs
StatePublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1616
ISSN (Print)1064-3745

Keywords

  • Bacterial vaginosis
  • Culture cell line
  • Fluorescence in situ hybridization (FISH)
  • Gardnerella vaginalis
  • Lactobacillus spp
  • Vaginal samples

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