Nanoparticles to Cross Biological Barriers

Thomas Moore; Elizabeth Graham; Brandon Mattix; Frank Alexis

doi:10.1201/b12303-8

Nanoparticles to Cross Biological Barriers

Thomas Moore
, Elizabeth Graham
, Brandon Mattix
, Frank Alexis

Clemson University College of Engineering, Computing and Applied Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

7 Scopus citations

Abstract

KEY TERMS: Drug delivery, pulmonary delivery, oral delivery, nasal delivery, transdermal delivery, circulation time, biodistribution, excretion, blood-brain barrier Polymeric nanoparticle delivery systems have the potential to signicantly impact the treatment of cancer. Nanoparticle drug delivery systems offer the ability to design a delivery vehicle that maximizes the therapeutic index of a drug encapsulated into nanoparticles (NPs), target it to cancerous tissue, and release it in a controlled manner for optimal dosing. This chapter describes the barriers associated with various delivery routes, specically tissue, cellular, and molecular. Nanoparticle delivery approaches across tissue barriers CONTENTS Abstract …………………………………………………………………………………………………….85 Introduction ……………………………………………………………………………………………..86 Clinical Impact of NPDDS……………………………………………………………………….. 87 Crossing Epithelial Barriers ………………………………………………………………………88.

Original language	English
Title of host publication	Biomaterials Science
Subtitle of host publication	An Integrated Clinical and Engineering Approach
Publisher	CRC Press
Pages	85-122
Number of pages	38
ISBN (Electronic)	9781439804056
ISBN (Print)	9780367381257
DOIs	https://doi.org/10.1201/b12303-8
State	Published - 1 Jan 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1201/b12303-8

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abstract = "KEY TERMS: Drug delivery, pulmonary delivery, oral delivery, nasal delivery, transdermal delivery, circulation time, biodistribution, excretion, blood-brain barrier Polymeric nanoparticle delivery systems have the potential to signicantly impact the treatment of cancer. Nanoparticle drug delivery systems offer the ability to design a delivery vehicle that maximizes the therapeutic index of a drug encapsulated into nanoparticles (NPs), target it to cancerous tissue, and release it in a controlled manner for optimal dosing. This chapter describes the barriers associated with various delivery routes, specically tissue, cellular, and molecular. Nanoparticle delivery approaches across tissue barriers CONTENTS Abstract …………………………………………………………………………………………………….85 Introduction ……………………………………………………………………………………………..86 Clinical Impact of NPDDS……………………………………………………………………….. 87 Crossing Epithelial Barriers ………………………………………………………………………88.",

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AU - Mattix, Brandon

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ER -

Nanoparticles to Cross Biological Barriers

Abstract

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