TY - JOUR
T1 - Nanotechnologies for noninvasive measurement of drug release
AU - Moore, Thomas
AU - Chen, Hongyu
AU - Morrison, Rachel
AU - Wang, Fenglin
AU - Anker, Jeffrey N.
AU - Alexis, Frank
PY - 2014/1/6
Y1 - 2014/1/6
N2 - A wide variety of chemotherapy and radiotherapy agents are available for treating cancer, but a critical challenge is to deliver these agents locally to cancer cells and tumors while minimizing side effects from systemic delivery. Nanomedicine uses nanoparticles with diameters in the range of ∼1-100 nm to encapsulate drugs and target them to tumors. The nanoparticle enhances local drug delivery efficiency to the tumors via entrapment in leaky tumor vasculature, molecular targeting to cells expressing cancer biomarkers, and/or magnetic targeting. In addition, the localization can be enhanced using triggered release in tumors via chemical, thermal, or optical signals. In order to optimize these nanoparticle drug delivery strategies, it is important to be able to image where the nanoparticles distribute and how rapidly they release their drug payloads. This Review aims to evaluate the current state of nanotechnology platforms for cancer theranostics (therapeutic and diagnostic particles) that are capable of noninvasive measurement of release kinetics.
AB - A wide variety of chemotherapy and radiotherapy agents are available for treating cancer, but a critical challenge is to deliver these agents locally to cancer cells and tumors while minimizing side effects from systemic delivery. Nanomedicine uses nanoparticles with diameters in the range of ∼1-100 nm to encapsulate drugs and target them to tumors. The nanoparticle enhances local drug delivery efficiency to the tumors via entrapment in leaky tumor vasculature, molecular targeting to cells expressing cancer biomarkers, and/or magnetic targeting. In addition, the localization can be enhanced using triggered release in tumors via chemical, thermal, or optical signals. In order to optimize these nanoparticle drug delivery strategies, it is important to be able to image where the nanoparticles distribute and how rapidly they release their drug payloads. This Review aims to evaluate the current state of nanotechnology platforms for cancer theranostics (therapeutic and diagnostic particles) that are capable of noninvasive measurement of release kinetics.
KW - cancer
KW - imaging delivery
KW - quantitative drug delivery
KW - theranostic nanomedicine
UR - http://www.scopus.com/inward/record.url?scp=84891806486&partnerID=8YFLogxK
U2 - 10.1021/mp400419k
DO - 10.1021/mp400419k
M3 - Artículo de revisión
C2 - 24215280
AN - SCOPUS:84891806486
SN - 1543-8384
VL - 11
SP - 24
EP - 39
JO - Molecular Pharmaceutics
JF - Molecular Pharmaceutics
IS - 1
ER -
