Nanotechnologies for noninvasive measurement of drug release

Thomas Moore, Hongyu Chen, Rachel Morrison, Fenglin Wang, Jeffrey N. Anker, Frank Alexis

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations

Abstract

A wide variety of chemotherapy and radiotherapy agents are available for treating cancer, but a critical challenge is to deliver these agents locally to cancer cells and tumors while minimizing side effects from systemic delivery. Nanomedicine uses nanoparticles with diameters in the range of ∼1-100 nm to encapsulate drugs and target them to tumors. The nanoparticle enhances local drug delivery efficiency to the tumors via entrapment in leaky tumor vasculature, molecular targeting to cells expressing cancer biomarkers, and/or magnetic targeting. In addition, the localization can be enhanced using triggered release in tumors via chemical, thermal, or optical signals. In order to optimize these nanoparticle drug delivery strategies, it is important to be able to image where the nanoparticles distribute and how rapidly they release their drug payloads. This Review aims to evaluate the current state of nanotechnology platforms for cancer theranostics (therapeutic and diagnostic particles) that are capable of noninvasive measurement of release kinetics.

Original languageEnglish
Pages (from-to)24-39
Number of pages16
JournalMolecular Pharmaceutics
Volume11
Issue number1
DOIs
StatePublished - 6 Jan 2014
Externally publishedYes

Keywords

  • cancer
  • imaging delivery
  • quantitative drug delivery
  • theranostic nanomedicine

Fingerprint

Dive into the research topics of 'Nanotechnologies for noninvasive measurement of drug release'. Together they form a unique fingerprint.

Cite this