Overweight/obesity and respiratory and allergic disease in children: International study of asthma and allergies in childhood (ISAAC) phase two

ISAAC Phase Two Steering Group

doi:10.1371/journal.pone.0113996

Overweight/obesity and respiratory and allergic disease in children: International study of asthma and allergies in childhood (ISAAC) phase two

ISAAC Phase Two Steering Group

Ulm University
Rome E Health Authority
Department of Epidemiology Lazio Regional Health Service
St. George's University of London
UHC 'Mother Teresa'
Pontifícia Universidade Católica do Rio Grande do Sul
Hospital Pedro Vicente Maldonado
Capital Institute of Paediatrics
Guangzhou Medical College
The Chinese University of Hong Kong
Prince of Wales Hospital Hong Kong
Tallinn Children's Hospital
Inserm
Center of Allergy & Immunology
Technische Universität Dresden
University of Münster
Ludwig Maximilian University of Munich
Komfo Anokye Teaching Hospital
National and Kapodistrian University of Athens
General Hospital of Athens
Hippokration General Hospital of Thessaloniki
Landspitali University Hospital
Torrecardenas Hospital
Jaslok Hospital & Research Centre
Catholic University of the Sacred Heart
Riga Stradins University
Institute for Risk Assessment Sciences
Utrecht University
Environmental and Occupational Health Group
Harvard University
Wageningen University & Research
University of Otago
Hawke's Bay Regional Hospital
Norwegian Institute of Public Health
University Hospital of North Norway
UiT the Arctic University of Norway
'Virgen de la Arrixaca' University Children's Hospital
University of Murcia
Hospital Universitario 12 de Octubre
Universitat de València
Clinic University Hospital
Dr. Peset University Hospital
Sundsvall Hospital
Linkoping University Hospital
University Hospital
Hacettepe University
Mersin University
Al-Quds University
St George's Hospital
Union Internationale Contre la Tuberculose et les Maladies Respiratoires
London School of Hygiene & Tropical Medicine
University of Auckland
Queens Medical Centre
Medical Research Institute of New Zealand
Karolinska Institutet
Massey University Wellington
Universidad de Santiago de Chile
University of Malta
Kenya Medical Research Institute
Murdoch Children's Research Institute

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

Background: Childhood obesity and asthma are increasing worldwide. A possible link between the two conditions has been postulated. Methods: Cross-sectional studies of stratified random samples of 8-12-year-old children (n=10 652) (16 centres in affluent and 8 centres in non-affluent countries) used the standardized methodology of ISAAC Phase Two. Respiratory and allergic symptoms were ascertained by parental questionnaires. Tests for allergic disease were performed. Height and weight were measured, and overweight and obesity were defined according to international definitions. Prevalence rates and prevalence odds ratios were calculated. Results: Overweight (odds ratio=1.14, 95%-confidence interval: 0.98; 1.33) and obesity (odds ratio=1.67, 95%-confidence interval: 1.25; 2.21) were related to wheeze. The relationship was stronger in affluent than in non-affluent centres. Similar results were found for cough and phlegm, rhinitis and eczema but the associations were mostly driven by children with wheeze. There was a clear association of overweight and obesity with airways obstruction (change in FEV1/FVC, 20.90, 95%-confidence interval: 21.33%; 20.47%, for overweight and 22.46%, 95%-confidence interval: 23.84%; 21.07%, for obesity) whereas the results for the other objective markers, including atopy, were null. Conclusions: Our data from a large international child population confirm that there is a strong relation of body mass index with wheeze especially in affluent countries. Moreover, body mass index is associated with an objective marker of airways obstruction (FEV1/FVC) but no other objective markers of respiratory and allergic disorders.

Original language	English
Article number	e113996
Journal	PLOS ONE
Volume	9
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0113996
State	Published - 4 Dec 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1371/journal.pone.0113996

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@article{f80337ab5a4e41cf89dc9fe85c0a91e6,

title = "Overweight/obesity and respiratory and allergic disease in children: International study of asthma and allergies in childhood (ISAAC) phase two",

abstract = "Background: Childhood obesity and asthma are increasing worldwide. A possible link between the two conditions has been postulated. Methods: Cross-sectional studies of stratified random samples of 8-12-year-old children (n=10 652) (16 centres in affluent and 8 centres in non-affluent countries) used the standardized methodology of ISAAC Phase Two. Respiratory and allergic symptoms were ascertained by parental questionnaires. Tests for allergic disease were performed. Height and weight were measured, and overweight and obesity were defined according to international definitions. Prevalence rates and prevalence odds ratios were calculated. Results: Overweight (odds ratio=1.14, 95\%-confidence interval: 0.98; 1.33) and obesity (odds ratio=1.67, 95\%-confidence interval: 1.25; 2.21) were related to wheeze. The relationship was stronger in affluent than in non-affluent centres. Similar results were found for cough and phlegm, rhinitis and eczema but the associations were mostly driven by children with wheeze. There was a clear association of overweight and obesity with airways obstruction (change in FEV1/FVC, 20.90, 95\%-confidence interval: 21.33\%; 20.47\%, for overweight and 22.46\%, 95\%-confidence interval: 23.84\%; 21.07\%, for obesity) whereas the results for the other objective markers, including atopy, were null. Conclusions: Our data from a large international child population confirm that there is a strong relation of body mass index with wheeze especially in affluent countries. Moreover, body mass index is associated with an objective marker of airways obstruction (FEV1/FVC) but no other objective markers of respiratory and allergic disorders.",

author = "\{ISAAC Phase Two Steering Group\} and Gudrun Weinmayr and Francesco Forastiere and Gisela B{\"u}chele and Andrea Jaensch and Strachan, \{David P.\} and Gabriele Nagel and Weiland, \{S. K.\} and C. Dentler and P. Rzehak and A. Priftanji and A. Shkurti and J. Simenati and E. Grabocka and K. Shyti and S. Agolli and A. Gurakuqi and Stein, \{R. T.\} and \{De Pereira\}, \{M. Urrutia\} and Jones, \{M. H.\} and Pitrez, \{P. M.\} and Cooper, \{P. J.\} and M. Chico and Chen, \{Y. Z.\} and Zhong, \{N. S.\} and Lai, \{C. K.W.\} and Wong, \{G. W.K.\} and Riikj{\"a}rv, \{M. A.\} and T. Annus and I. Annesi-Maesano and M. Gotua and M. Rukhadze and T. Abramidze and I. Kvachadze and L. Karsanidze and M. Kiladze and N. Dolidze and W. Leupold and U. Keil and \{Von Mutius\}, E. and P. Arthur and E. Addo-Yobo and C. Gratziou and K. Priftis and A. Papadopoulou and C. Katsardis and J. Tsanakas and E. Hatziagorou and F. Kirvassilis and M. Clausen and Maldonado, \{A. Losilla\}",

note = "Publisher Copyright: {\textcopyright} 2014 Weinmayr et al.",

year = "2014",

month = dec,

day = "4",

doi = "10.1371/journal.pone.0113996",

language = "Ingl{\'e}s",

volume = "9",

journal = "PLOS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "12",

}

TY - JOUR

T1 - Overweight/obesity and respiratory and allergic disease in children

T2 - International study of asthma and allergies in childhood (ISAAC) phase two

AU - ISAAC Phase Two Steering Group

AU - Weinmayr, Gudrun

AU - Forastiere, Francesco

AU - Büchele, Gisela

AU - Jaensch, Andrea

AU - Strachan, David P.

AU - Nagel, Gabriele

AU - Weiland, S. K.

AU - Dentler, C.

AU - Rzehak, P.

AU - Priftanji, A.

AU - Shkurti, A.

AU - Simenati, J.

AU - Grabocka, E.

AU - Shyti, K.

AU - Agolli, S.

AU - Gurakuqi, A.

AU - Stein, R. T.

AU - De Pereira, M. Urrutia

AU - Jones, M. H.

AU - Pitrez, P. M.

AU - Cooper, P. J.

AU - Chico, M.

AU - Chen, Y. Z.

AU - Zhong, N. S.

AU - Lai, C. K.W.

AU - Wong, G. W.K.

AU - Riikjärv, M. A.

AU - Annus, T.

AU - Annesi-Maesano, I.

AU - Gotua, M.

AU - Rukhadze, M.

AU - Abramidze, T.

AU - Kvachadze, I.

AU - Karsanidze, L.

AU - Kiladze, M.

AU - Dolidze, N.

AU - Leupold, W.

AU - Keil, U.

AU - Von Mutius, E.

AU - Arthur, P.

AU - Addo-Yobo, E.

AU - Gratziou, C.

AU - Priftis, K.

AU - Papadopoulou, A.

AU - Katsardis, C.

AU - Tsanakas, J.

AU - Hatziagorou, E.

AU - Kirvassilis, F.

AU - Clausen, M.

AU - Maldonado, A. Losilla

PY - 2014/12/4

Y1 - 2014/12/4

N2 - Background: Childhood obesity and asthma are increasing worldwide. A possible link between the two conditions has been postulated. Methods: Cross-sectional studies of stratified random samples of 8-12-year-old children (n=10 652) (16 centres in affluent and 8 centres in non-affluent countries) used the standardized methodology of ISAAC Phase Two. Respiratory and allergic symptoms were ascertained by parental questionnaires. Tests for allergic disease were performed. Height and weight were measured, and overweight and obesity were defined according to international definitions. Prevalence rates and prevalence odds ratios were calculated. Results: Overweight (odds ratio=1.14, 95%-confidence interval: 0.98; 1.33) and obesity (odds ratio=1.67, 95%-confidence interval: 1.25; 2.21) were related to wheeze. The relationship was stronger in affluent than in non-affluent centres. Similar results were found for cough and phlegm, rhinitis and eczema but the associations were mostly driven by children with wheeze. There was a clear association of overweight and obesity with airways obstruction (change in FEV1/FVC, 20.90, 95%-confidence interval: 21.33%; 20.47%, for overweight and 22.46%, 95%-confidence interval: 23.84%; 21.07%, for obesity) whereas the results for the other objective markers, including atopy, were null. Conclusions: Our data from a large international child population confirm that there is a strong relation of body mass index with wheeze especially in affluent countries. Moreover, body mass index is associated with an objective marker of airways obstruction (FEV1/FVC) but no other objective markers of respiratory and allergic disorders.

AB - Background: Childhood obesity and asthma are increasing worldwide. A possible link between the two conditions has been postulated. Methods: Cross-sectional studies of stratified random samples of 8-12-year-old children (n=10 652) (16 centres in affluent and 8 centres in non-affluent countries) used the standardized methodology of ISAAC Phase Two. Respiratory and allergic symptoms were ascertained by parental questionnaires. Tests for allergic disease were performed. Height and weight were measured, and overweight and obesity were defined according to international definitions. Prevalence rates and prevalence odds ratios were calculated. Results: Overweight (odds ratio=1.14, 95%-confidence interval: 0.98; 1.33) and obesity (odds ratio=1.67, 95%-confidence interval: 1.25; 2.21) were related to wheeze. The relationship was stronger in affluent than in non-affluent centres. Similar results were found for cough and phlegm, rhinitis and eczema but the associations were mostly driven by children with wheeze. There was a clear association of overweight and obesity with airways obstruction (change in FEV1/FVC, 20.90, 95%-confidence interval: 21.33%; 20.47%, for overweight and 22.46%, 95%-confidence interval: 23.84%; 21.07%, for obesity) whereas the results for the other objective markers, including atopy, were null. Conclusions: Our data from a large international child population confirm that there is a strong relation of body mass index with wheeze especially in affluent countries. Moreover, body mass index is associated with an objective marker of airways obstruction (FEV1/FVC) but no other objective markers of respiratory and allergic disorders.

UR - https://www.scopus.com/pages/publications/84915746668

U2 - 10.1371/journal.pone.0113996

DO - 10.1371/journal.pone.0113996

M3 - Artículo

C2 - 25474308

AN - SCOPUS:84915746668

SN - 1932-6203

VL - 9

JO - PLOS ONE

JF - PLOS ONE

IS - 12

M1 - e113996

ER -

Overweight/obesity and respiratory and allergic disease in children: International study of asthma and allergies in childhood (ISAAC) phase two

Abstract

UN SDGs

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