TY - JOUR
T1 - Preeclampsia is associated with a decrease in plasma coenzyme Q10 levels
AU - Teran, Enrique
AU - Racines-Orbe, Marcia
AU - Vivero, Sandra
AU - Escudero, Carlos
AU - Molina, Gustavo
AU - Calle, Andres
PY - 2003/12/1
Y1 - 2003/12/1
N2 - Preeclampsia is a common (~7% of all pregnancies) disorder of human pregnancy in which the normal hemodynamic response to pregnancy is compromised. Despite many years of intensive research, the pathogenesis of preeclampsia is still not fully understood. The objective of the present study was to investigate the concentration of coenzyme Q10 in normal pregnancy and preeclampsia. Pregnant women (n = 18), women with preeclampsia (n = 12), and nonpregnant normotensive women (n = 22) were included. Plasma levels of coenzyme Q10 were measured by high-performance liquid chromatography. Plasma coenzyme Q10 levels were significantly higher in normal pregnant women (mean = 1.08, SEM = 0.08 umol/l; p < .005) in comparison to nonpregnant women (mean = 0.86, SEM = 0.16 umol/l) and women with preeclampsia (mean = 0.7, SEM = 0.03 umol/l; p < .0001). These results demonstrated that during preeclampsia there is a significant decrease in plasma levels of coenzyme Q10 compared to normal pregnant women, and compared to those who are not pregnant.
AB - Preeclampsia is a common (~7% of all pregnancies) disorder of human pregnancy in which the normal hemodynamic response to pregnancy is compromised. Despite many years of intensive research, the pathogenesis of preeclampsia is still not fully understood. The objective of the present study was to investigate the concentration of coenzyme Q10 in normal pregnancy and preeclampsia. Pregnant women (n = 18), women with preeclampsia (n = 12), and nonpregnant normotensive women (n = 22) were included. Plasma levels of coenzyme Q10 were measured by high-performance liquid chromatography. Plasma coenzyme Q10 levels were significantly higher in normal pregnant women (mean = 1.08, SEM = 0.08 umol/l; p < .005) in comparison to nonpregnant women (mean = 0.86, SEM = 0.16 umol/l) and women with preeclampsia (mean = 0.7, SEM = 0.03 umol/l; p < .0001). These results demonstrated that during preeclampsia there is a significant decrease in plasma levels of coenzyme Q10 compared to normal pregnant women, and compared to those who are not pregnant.
KW - Coenzyme Q10
KW - Free radicals
KW - Oxidative stress
KW - Preeclampsia
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=0344875068&partnerID=8YFLogxK
U2 - 10.1016/j.freeradbiomed.2003.08.004
DO - 10.1016/j.freeradbiomed.2003.08.004
M3 - Artículo
C2 - 14642393
AN - SCOPUS:0344875068
SN - 0891-5849
VL - 35
SP - 1453
EP - 1456
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
IS - 11
ER -