Radioactive gold nanocluster (198-AuNCs) showed inhibitory effects on cancer cells lines

Shijin Xuan; Aline Oliveira da Silva de Barros; Rogério Chaffin Nunes; Eduardo Ricci-Junior; Ademir Xavier da Silva; Muhammad Sahid; Luciana Magalhaes Rebelo Alencar; Clenilton Costa dos Santos; Veronica Morandi; Frank Alexis; Surtaj H. Iram; Ralph Santos-Oliveira

doi:10.1080/21691401.2020.1821698

Radioactive gold nanocluster (198-AuNCs) showed inhibitory effects on cancer cells lines

Shijin Xuan
, Aline Oliveira da Silva de Barros
, Rogério Chaffin Nunes
, Eduardo Ricci-Junior
, Ademir Xavier da Silva
, Muhammad Sahid
, Luciana Magalhaes Rebelo Alencar
, Clenilton Costa dos Santos
, Veronica Morandi
, Frank Alexis
, Surtaj H. Iram
, Ralph Santos-Oliveira^*

^*Corresponding author for this work

Shandong First Medical University & Shandong Academy of Medical Sciences
Nuclear Engineering Institute
Museu Nacional/UFRJ
Pakistan Nuclear Regulatory Authority
Federal University of Maranhão
Universidade do Estado do Rio de Janeiro
Clemson University College of Engineering, Computing and Applied Sciences
Universidad Yachay Tech
South Dakota State University

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Cancer is a global epidemic disease responsible for over ten millions death worldwide. The early diagnosis and the precise treatment with reduced adverse reactions are the main goal worldwide. In this study, we produced, characterized and evaluated (in vitro) in three different cancer cell lines (protaste, breast and melanoma) a radioactive gold nanocluster (R-AuNC) (¹⁹⁸Au25(Capt)18). The pharmacokinetics as the influence in the ABC transporter (MRP1 Efflux Transporter Protein) was also evaluated. The results showed that R-AuNC (¹⁹⁸Au25(Capt)18) are capable to kill the cancer cells lines of protaste, breast and melanoma. The pharmacokinetics showed a fast clearance and great volume of distribution, confirming the use of R-AuNC as nanomedicine for cancer treatment. Finally, the ABC transporter assay corroborated that the R-AuNC (¹⁹⁸Au25(Capt)18) has no risk of being pumped out of cells by this efflux transporter. The results validate the use of gold nanoparticles as therapeutic nanomedicine for cancer treatment.

Original language	English
Pages (from-to)	1214-1221
Number of pages	8
Journal	Artificial Cells, Nanomedicine and Biotechnology
Volume	48
Issue number	1
DOIs	https://doi.org/10.1080/21691401.2020.1821698
State	Published - 1 Jan 2020
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Radiopharmaceuticals
cancer
nano-radiopharmaceuticals
theranostic

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10.1080/21691401.2020.1821698

Cite this

Xuan, S., de Barros, A. O. D. S., Nunes, R. C., Ricci-Junior, E., da Silva, A. X., Sahid, M., Alencar, L. M. R., dos Santos, C. C., Morandi, V., Alexis, F., Iram, S. H., & Santos-Oliveira, R. (2020). Radioactive gold nanocluster (198-AuNCs) showed inhibitory effects on cancer cells lines. Artificial Cells, Nanomedicine and Biotechnology, 48(1), 1214-1221. https://doi.org/10.1080/21691401.2020.1821698

@article{7933ecefffc449179a7c27595227f833,

title = "Radioactive gold nanocluster (198-AuNCs) showed inhibitory effects on cancer cells lines",

abstract = "Cancer is a global epidemic disease responsible for over ten millions death worldwide. The early diagnosis and the precise treatment with reduced adverse reactions are the main goal worldwide. In this study, we produced, characterized and evaluated (in vitro) in three different cancer cell lines (protaste, breast and melanoma) a radioactive gold nanocluster (R-AuNC) (198Au25(Capt)18). The pharmacokinetics as the influence in the ABC transporter (MRP1 Efflux Transporter Protein) was also evaluated. The results showed that R-AuNC (198Au25(Capt)18) are capable to kill the cancer cells lines of protaste, breast and melanoma. The pharmacokinetics showed a fast clearance and great volume of distribution, confirming the use of R-AuNC as nanomedicine for cancer treatment. Finally, the ABC transporter assay corroborated that the R-AuNC (198Au25(Capt)18) has no risk of being pumped out of cells by this efflux transporter. The results validate the use of gold nanoparticles as therapeutic nanomedicine for cancer treatment.",

keywords = "Radiopharmaceuticals, cancer, nano-radiopharmaceuticals, theranostic",

author = "Shijin Xuan and \{de Barros\}, \{Aline Oliveira da Silva\} and Nunes, \{Rog{\'e}rio Chaffin\} and Eduardo Ricci-Junior and \{da Silva\}, \{Ademir Xavier\} and Muhammad Sahid and Alencar, \{Luciana Magalhaes Rebelo\} and \{dos Santos\}, \{Clenilton Costa\} and Veronica Morandi and Frank Alexis and Iram, \{Surtaj H.\} and Ralph Santos-Oliveira",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s). Published by Informa UK Limited, trading as Taylor \& Francis Group.",

year = "2020",

month = jan,

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doi = "10.1080/21691401.2020.1821698",

language = "Ingl{\'e}s",

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journal = "Artificial Cells, Nanomedicine and Biotechnology",

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Xuan, S, de Barros, AODS, Nunes, RC, Ricci-Junior, E, da Silva, AX, Sahid, M, Alencar, LMR, dos Santos, CC, Morandi, V, Alexis, F, Iram, SH & Santos-Oliveira, R 2020, 'Radioactive gold nanocluster (198-AuNCs) showed inhibitory effects on cancer cells lines', Artificial Cells, Nanomedicine and Biotechnology, vol. 48, no. 1, pp. 1214-1221. https://doi.org/10.1080/21691401.2020.1821698

TY - JOUR

T1 - Radioactive gold nanocluster (198-AuNCs) showed inhibitory effects on cancer cells lines

AU - Xuan, Shijin

AU - de Barros, Aline Oliveira da Silva

AU - Nunes, Rogério Chaffin

AU - Ricci-Junior, Eduardo

AU - da Silva, Ademir Xavier

AU - Sahid, Muhammad

AU - Alencar, Luciana Magalhaes Rebelo

AU - dos Santos, Clenilton Costa

AU - Morandi, Veronica

AU - Alexis, Frank

AU - Iram, Surtaj H.

AU - Santos-Oliveira, Ralph

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Cancer is a global epidemic disease responsible for over ten millions death worldwide. The early diagnosis and the precise treatment with reduced adverse reactions are the main goal worldwide. In this study, we produced, characterized and evaluated (in vitro) in three different cancer cell lines (protaste, breast and melanoma) a radioactive gold nanocluster (R-AuNC) (198Au25(Capt)18). The pharmacokinetics as the influence in the ABC transporter (MRP1 Efflux Transporter Protein) was also evaluated. The results showed that R-AuNC (198Au25(Capt)18) are capable to kill the cancer cells lines of protaste, breast and melanoma. The pharmacokinetics showed a fast clearance and great volume of distribution, confirming the use of R-AuNC as nanomedicine for cancer treatment. Finally, the ABC transporter assay corroborated that the R-AuNC (198Au25(Capt)18) has no risk of being pumped out of cells by this efflux transporter. The results validate the use of gold nanoparticles as therapeutic nanomedicine for cancer treatment.

AB - Cancer is a global epidemic disease responsible for over ten millions death worldwide. The early diagnosis and the precise treatment with reduced adverse reactions are the main goal worldwide. In this study, we produced, characterized and evaluated (in vitro) in three different cancer cell lines (protaste, breast and melanoma) a radioactive gold nanocluster (R-AuNC) (198Au25(Capt)18). The pharmacokinetics as the influence in the ABC transporter (MRP1 Efflux Transporter Protein) was also evaluated. The results showed that R-AuNC (198Au25(Capt)18) are capable to kill the cancer cells lines of protaste, breast and melanoma. The pharmacokinetics showed a fast clearance and great volume of distribution, confirming the use of R-AuNC as nanomedicine for cancer treatment. Finally, the ABC transporter assay corroborated that the R-AuNC (198Au25(Capt)18) has no risk of being pumped out of cells by this efflux transporter. The results validate the use of gold nanoparticles as therapeutic nanomedicine for cancer treatment.

KW - Radiopharmaceuticals

KW - cancer

KW - nano-radiopharmaceuticals

KW - theranostic

UR - https://www.scopus.com/pages/publications/85091128421

U2 - 10.1080/21691401.2020.1821698

DO - 10.1080/21691401.2020.1821698

M3 - Artículo

C2 - 32940067

AN - SCOPUS:85091128421

SN - 2169-1401

VL - 48

SP - 1214

EP - 1221

JO - Artificial Cells, Nanomedicine and Biotechnology

JF - Artificial Cells, Nanomedicine and Biotechnology

IS - 1

ER -

Radioactive gold nanocluster (198-AuNCs) showed inhibitory effects on cancer cells lines

Abstract

UN SDGs

Keywords

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