Self-assembled lipid-polymer hybrid nanoparticles: A robust drug delivery platform

Liangfang Zhang, Juliana M. Chan, Frank X. Gu, June Wha Rhee, Andrew Z. Wang, Aleksandar F. Radovic-Moreno, Frank Alexis, Robert Langer, Omid C. Farokhzad

Research output: Contribution to journalArticlepeer-review

845 Scopus citations


We report the engineering of a novel lipid-polymer hybrid nanoparticle (NP) as a robust drug delivery platform, with high drug encapsulation yield, tunable and sustained drug release profile, excellent serum stability, and potential for differential targeting of cells or tissues. The NP comprises three distinct functional components: (i) a hydrophobic polymeric core where poorly water-soluble drugs can be encapsulated; (ii) a hydrophilic polymeric shell with antibiofouling properties to enhance NP stability and systemic circulation half-life; and (iii) a lipid monolayer at the interface of the core and the shell that acts as a molecular fence to promote drug retention inside the polymeric core, thereby enhancing drug encapsulation efficiency, increasing drug loading yield, and controlling drug release. The NP is prepared by self-assembly through a single-step nanoprecipitation method in a reproducible and predictable manner, making it potentially suitable for scale-up.

Original languageEnglish
Pages (from-to)1696-1702
Number of pages7
JournalACS Nano
Issue number8
StatePublished - Aug 2008
Externally publishedYes


  • Drug delivery
  • Liposome
  • Nanoprecipitation
  • Polymeric nanoparticle
  • Self-assembly


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