Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy

Andrew Z. Wang; Vaishali Bagalkot; Christophoros C. Vasilliou; Frank Gu; Frank Alexis; Liangfang Zhang; Mariam Shaikh; Kai Yuet; Michael J. Cima; Robert Langer; Philip W. Kantoff; Neil H. Bander; Sangyong Jon; Omid C. Farokhzad

doi:10.1002/cmdc.200800091

Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy

Andrew Z. Wang
, Vaishali Bagalkot
, Christophoros C. Vasilliou
, Frank Gu
, Frank Alexis
, Liangfang Zhang
, Mariam Shaikh
, Kai Yuet
, Michael J. Cima
, Robert Langer
, Philip W. Kantoff
, Neil H. Bander
, Sangyong Jon^*
, Omid C. Farokhzad

^*Corresponding author for this work

Brigham and Women's Hospital
Massachusetts Institute of Technology
Gwangju Institute of Science and Technology
Massachusetts Institute of Technology
Harvard University
Cornell University

Research output: Contribution to journal › Article › peer-review

294 Scopus citations

Abstract

(Chemical Equation Presented) Multifunctional superparamagnetic iron oxide nanoparticles: Herein we report a novel, targeted, iron oxide nanoparticle for combined prostate cancer imaging and therapy. By conjugating an aptamer to a thermally stable iron oxide nanoparticle, we have demonstrated that bioconjugates can detect prostate cancer cells with high sensitivity and specificity. Furthermore, the bioconjugates can be used to deliver targeted chemotherapy.

Original language	English
Pages (from-to)	1311-1315
Number of pages	5
Journal	ChemMedChem
Volume	3
Issue number	9
DOIs	https://doi.org/10.1002/cmdc.200800091
State	Published - 15 Sep 2008
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Doxorubicin
Nanoparticles
Superparamagnetic
TCL-SPION

Access to Document

10.1002/cmdc.200800091

Cite this

Wang, A. Z., Bagalkot, V., Vasilliou, C. C., Gu, F., Alexis, F., Zhang, L., Shaikh, M., Yuet, K., Cima, M. J., Langer, R., Kantoff, P. W., Bander, N. H., Jon, S., & Farokhzad, O. C. (2008). Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy. ChemMedChem, 3(9), 1311-1315. https://doi.org/10.1002/cmdc.200800091

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title = "Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy",

abstract = "(Chemical Equation Presented) Multifunctional superparamagnetic iron oxide nanoparticles: Herein we report a novel, targeted, iron oxide nanoparticle for combined prostate cancer imaging and therapy. By conjugating an aptamer to a thermally stable iron oxide nanoparticle, we have demonstrated that bioconjugates can detect prostate cancer cells with high sensitivity and specificity. Furthermore, the bioconjugates can be used to deliver targeted chemotherapy.",

keywords = "Doxorubicin, Nanoparticles, Superparamagnetic, TCL-SPION",

author = "Wang, \{Andrew Z.\} and Vaishali Bagalkot and Vasilliou, \{Christophoros C.\} and Frank Gu and Frank Alexis and Liangfang Zhang and Mariam Shaikh and Kai Yuet and Cima, \{Michael J.\} and Robert Langer and Kantoff, \{Philip W.\} and Bander, \{Neil H.\} and Sangyong Jon and Farokhzad, \{Omid C.\}",

year = "2008",

month = sep,

day = "15",

doi = "10.1002/cmdc.200800091",

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AU - Wang, Andrew Z.

AU - Bagalkot, Vaishali

AU - Vasilliou, Christophoros C.

AU - Gu, Frank

AU - Alexis, Frank

AU - Zhang, Liangfang

AU - Shaikh, Mariam

AU - Yuet, Kai

AU - Cima, Michael J.

AU - Langer, Robert

AU - Kantoff, Philip W.

AU - Bander, Neil H.

AU - Jon, Sangyong

AU - Farokhzad, Omid C.

PY - 2008/9/15

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N2 - (Chemical Equation Presented) Multifunctional superparamagnetic iron oxide nanoparticles: Herein we report a novel, targeted, iron oxide nanoparticle for combined prostate cancer imaging and therapy. By conjugating an aptamer to a thermally stable iron oxide nanoparticle, we have demonstrated that bioconjugates can detect prostate cancer cells with high sensitivity and specificity. Furthermore, the bioconjugates can be used to deliver targeted chemotherapy.

AB - (Chemical Equation Presented) Multifunctional superparamagnetic iron oxide nanoparticles: Herein we report a novel, targeted, iron oxide nanoparticle for combined prostate cancer imaging and therapy. By conjugating an aptamer to a thermally stable iron oxide nanoparticle, we have demonstrated that bioconjugates can detect prostate cancer cells with high sensitivity and specificity. Furthermore, the bioconjugates can be used to deliver targeted chemotherapy.

KW - Doxorubicin

KW - Nanoparticles

KW - Superparamagnetic

KW - TCL-SPION

UR - https://www.scopus.com/pages/publications/54849404705

U2 - 10.1002/cmdc.200800091

DO - 10.1002/cmdc.200800091

M3 - Artículo

C2 - 18613203

AN - SCOPUS:54849404705

SN - 1860-7179

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SP - 1311

EP - 1315

JO - ChemMedChem

JF - ChemMedChem

IS - 9

ER -

Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy

Abstract

UN SDGs

Keywords

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