Symptomatic hemorrhage after alteplase therapy not due to silent ischemia

Michael D. Hill; Philip A. Barber; Andrew M. Demchuk; Robert J. Sevick; Richard Frayne; Alastair M. Buchan

doi:10.1186/1471-2377-1-1

Symptomatic hemorrhage after alteplase therapy not due to silent ischemia

Michael D. Hill^*
, Philip A. Barber
, Andrew M. Demchuk
, Robert J. Sevick
, Richard Frayne
, Alastair M. Buchan

^*Corresponding author for this work

University of Calgary

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Background: Stroke thrombolysis-related intracerebral hemorrhage may occur remotely from the anatomical site of ischemia. One postulated mechanism for this is simultaneous multiple embolization with hemorrhage into a "silent" area of ischemia. Results: A patient suffered a disabling stroke affecting the right cerebral hemisphere. He was treated with intravenous alteplase and underwent extensive early imaging with multimodal MRI. Several hours after treatment he developed a brainstem hemorrhage despite having no evidence of ischemia on DWI MRI in the brainstem. Conclusion: Not all occurrences of remote ICH after stroke thrombolysis are secondary to multiple emboli with silent ischemia.

Original language	English
Article number	1
Journal	BMC Neurology
Volume	1
DOIs	https://doi.org/10.1186/1471-2377-1-1
State	Published - 19 Jan 2001
Externally published	Yes

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title = "Symptomatic hemorrhage after alteplase therapy not due to silent ischemia",

abstract = "Background: Stroke thrombolysis-related intracerebral hemorrhage may occur remotely from the anatomical site of ischemia. One postulated mechanism for this is simultaneous multiple embolization with hemorrhage into a {"}silent{"} area of ischemia. Results: A patient suffered a disabling stroke affecting the right cerebral hemisphere. He was treated with intravenous alteplase and underwent extensive early imaging with multimodal MRI. Several hours after treatment he developed a brainstem hemorrhage despite having no evidence of ischemia on DWI MRI in the brainstem. Conclusion: Not all occurrences of remote ICH after stroke thrombolysis are secondary to multiple emboli with silent ischemia.",

author = "Hill, \{Michael D.\} and Barber, \{Philip A.\} and Demchuk, \{Andrew M.\} and Sevick, \{Robert J.\} and Richard Frayne and Buchan, \{Alastair M.\}",

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T1 - Symptomatic hemorrhage after alteplase therapy not due to silent ischemia

AU - Hill, Michael D.

AU - Barber, Philip A.

AU - Demchuk, Andrew M.

AU - Sevick, Robert J.

AU - Frayne, Richard

AU - Buchan, Alastair M.

PY - 2001/1/19

Y1 - 2001/1/19

N2 - Background: Stroke thrombolysis-related intracerebral hemorrhage may occur remotely from the anatomical site of ischemia. One postulated mechanism for this is simultaneous multiple embolization with hemorrhage into a "silent" area of ischemia. Results: A patient suffered a disabling stroke affecting the right cerebral hemisphere. He was treated with intravenous alteplase and underwent extensive early imaging with multimodal MRI. Several hours after treatment he developed a brainstem hemorrhage despite having no evidence of ischemia on DWI MRI in the brainstem. Conclusion: Not all occurrences of remote ICH after stroke thrombolysis are secondary to multiple emboli with silent ischemia.

AB - Background: Stroke thrombolysis-related intracerebral hemorrhage may occur remotely from the anatomical site of ischemia. One postulated mechanism for this is simultaneous multiple embolization with hemorrhage into a "silent" area of ischemia. Results: A patient suffered a disabling stroke affecting the right cerebral hemisphere. He was treated with intravenous alteplase and underwent extensive early imaging with multimodal MRI. Several hours after treatment he developed a brainstem hemorrhage despite having no evidence of ischemia on DWI MRI in the brainstem. Conclusion: Not all occurrences of remote ICH after stroke thrombolysis are secondary to multiple emboli with silent ischemia.

UR - https://www.scopus.com/pages/publications/2642532966

U2 - 10.1186/1471-2377-1-1

DO - 10.1186/1471-2377-1-1

M3 - Artículo

C2 - 11208259

AN - SCOPUS:2642532966

SN - 1471-2377

VL - 1

JO - BMC Neurology

JF - BMC Neurology

M1 - 1

ER -

Symptomatic hemorrhage after alteplase therapy not due to silent ischemia

Abstract

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