Synthesis and conjugation of a triiodohydroxylamine for the preparation of highly X-ray opaque poly(ε-caprolactone) materials

Brooke A. Van Horn; Lundy L. Davis; Samantha E. Nicolau; Emma E. Burry; Victoria O. Bailey; Fernanda D. Guerra; Frank Alexis; Daniel C. Whitehead

doi:10.1002/pola.28436

Synthesis and conjugation of a triiodohydroxylamine for the preparation of highly X-ray opaque poly(ε-caprolactone) materials

Brooke A. Van Horn^*
, Lundy L. Davis
, Samantha E. Nicolau
, Emma E. Burry
, Victoria O. Bailey
, Fernanda D. Guerra
, Frank Alexis
, Daniel C. Whitehead

^*Corresponding author for this work

College of Charleston
Clemson University College of Engineering, Computing and Applied Sciences
Clemson University

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

To address a need for highly X-ray opaque biodegradable materials, a series of poly(ε-caprolactone) derivatives were prepared using oxime post-polymerization modification to conjugate two different iodinated hydroxylamines. These materials were synthesized with up to 32 wt. % iodine content and demonstrated improved X-ray contrast relative to both the ketone precursors and previously reported monoiodinated materials.

Original language	English
Pages (from-to)	787-793
Number of pages	7
Journal	Journal of Polymer Science, Part A: Polymer Chemistry
Volume	55
Issue number	5
DOIs	https://doi.org/10.1002/pola.28436
State	Published - 1 Mar 2017
Externally published	Yes

Keywords

X-ray
conjugation
iodine
oxime
polycaprolactone

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10.1002/pola.28436

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@article{33274719ef554012bad3e3fae50a03c4,

title = "Synthesis and conjugation of a triiodohydroxylamine for the preparation of highly X-ray opaque poly(ε-caprolactone) materials",

abstract = "To address a need for highly X-ray opaque biodegradable materials, a series of poly(ε-caprolactone) derivatives were prepared using oxime post-polymerization modification to conjugate two different iodinated hydroxylamines. These materials were synthesized with up to 32 wt. \% iodine content and demonstrated improved X-ray contrast relative to both the ketone precursors and previously reported monoiodinated materials.",

keywords = "X-ray, conjugation, iodine, oxime, polycaprolactone",

author = "\{Van Horn\}, \{Brooke A.\} and Davis, \{Lundy L.\} and Nicolau, \{Samantha E.\} and Burry, \{Emma E.\} and Bailey, \{Victoria O.\} and Guerra, \{Fernanda D.\} and Frank Alexis and Whitehead, \{Daniel C.\}",

note = "Publisher Copyright: {\textcopyright} 2016 Wiley Periodicals, Inc.",

year = "2017",

month = mar,

day = "1",

doi = "10.1002/pola.28436",

language = "Ingl{\'e}s",

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journal = "Journal of Polymer Science, Part A: Polymer Chemistry",

issn = "0887-624X",

publisher = "John Wiley \& Sons Inc.",

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TY - JOUR

T1 - Synthesis and conjugation of a triiodohydroxylamine for the preparation of highly X-ray opaque poly(ε-caprolactone) materials

AU - Van Horn, Brooke A.

AU - Davis, Lundy L.

AU - Nicolau, Samantha E.

AU - Burry, Emma E.

AU - Bailey, Victoria O.

AU - Guerra, Fernanda D.

AU - Alexis, Frank

AU - Whitehead, Daniel C.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - To address a need for highly X-ray opaque biodegradable materials, a series of poly(ε-caprolactone) derivatives were prepared using oxime post-polymerization modification to conjugate two different iodinated hydroxylamines. These materials were synthesized with up to 32 wt. % iodine content and demonstrated improved X-ray contrast relative to both the ketone precursors and previously reported monoiodinated materials.

AB - To address a need for highly X-ray opaque biodegradable materials, a series of poly(ε-caprolactone) derivatives were prepared using oxime post-polymerization modification to conjugate two different iodinated hydroxylamines. These materials were synthesized with up to 32 wt. % iodine content and demonstrated improved X-ray contrast relative to both the ketone precursors and previously reported monoiodinated materials.

KW - X-ray

KW - conjugation

KW - iodine

KW - oxime

KW - polycaprolactone

UR - https://www.scopus.com/pages/publications/85007409449

U2 - 10.1002/pola.28436

DO - 10.1002/pola.28436

M3 - Artículo

AN - SCOPUS:85007409449

SN - 0887-624X

VL - 55

SP - 787

EP - 793

JO - Journal of Polymer Science, Part A: Polymer Chemistry

JF - Journal of Polymer Science, Part A: Polymer Chemistry

IS - 5

ER -

Synthesis and conjugation of a triiodohydroxylamine for the preparation of highly X-ray opaque poly(ε-caprolactone) materials

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Keywords

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