Tissue-specific disruption of the growth hormone receptor (GHR) in mice: An update

Silvana Duran-Ortiz; Vanessa Noboa; John J. Kopchick

doi:10.1016/j.ghir.2019.12.004

Tissue-specific disruption of the growth hormone receptor (GHR) in mice: An update

Silvana Duran-Ortiz
, Vanessa Noboa
, John J. Kopchick^*

^*Corresponding author for this work

Medicina

Ohio University
Molecular and Cellular Biology Program
Ohio University

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The Growth hormone receptor (GHR) is expressed in many cells/tissues in the body. To investigate the specific metabolic effects of GH action in distinct tissues, several tissue-specific GHR gene disrupted or knockout (KO) mouse lines have been generated. Previously, we have described the effects of GHRKO in several known insulin sensitive tissues, namely liver, muscle and adipose tissue. In this review, we further explore and summarize the main findings of recently published GHRKO results in liver, adipocytes, intestine, bone, brain and heart.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Growth Hormone and IGF Research
Volume	51
DOIs	https://doi.org/10.1016/j.ghir.2019.12.004
State	Published - Apr 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adipose tissue
Bone
Brain
Growth hormone receptor
Heart
IGF-I
Intestine
Liver
Macrophages
Tissue-specific

Access to Document

10.1016/j.ghir.2019.12.004

Cite this

@article{9a8b128c110b49fbb55266f417bf32e3,

title = "Tissue-specific disruption of the growth hormone receptor (GHR) in mice: An update",

abstract = "The Growth hormone receptor (GHR) is expressed in many cells/tissues in the body. To investigate the specific metabolic effects of GH action in distinct tissues, several tissue-specific GHR gene disrupted or knockout (KO) mouse lines have been generated. Previously, we have described the effects of GHRKO in several known insulin sensitive tissues, namely liver, muscle and adipose tissue. In this review, we further explore and summarize the main findings of recently published GHRKO results in liver, adipocytes, intestine, bone, brain and heart.",

keywords = "Adipose tissue, Bone, Brain, Growth hormone receptor, Heart, IGF-I, Intestine, Liver, Macrophages, Tissue-specific",

author = "Silvana Duran-Ortiz and Vanessa Noboa and Kopchick, \{John J.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2020",

month = apr,

doi = "10.1016/j.ghir.2019.12.004",

language = "Ingl{\'e}s",

volume = "51",

pages = "1--5",

journal = "Growth Hormone and IGF Research",

issn = "1096-6374",

publisher = "Churchill Livingstone",

}

TY - JOUR

T1 - Tissue-specific disruption of the growth hormone receptor (GHR) in mice

T2 - An update

AU - Duran-Ortiz, Silvana

AU - Noboa, Vanessa

AU - Kopchick, John J.

PY - 2020/4

Y1 - 2020/4

N2 - The Growth hormone receptor (GHR) is expressed in many cells/tissues in the body. To investigate the specific metabolic effects of GH action in distinct tissues, several tissue-specific GHR gene disrupted or knockout (KO) mouse lines have been generated. Previously, we have described the effects of GHRKO in several known insulin sensitive tissues, namely liver, muscle and adipose tissue. In this review, we further explore and summarize the main findings of recently published GHRKO results in liver, adipocytes, intestine, bone, brain and heart.

AB - The Growth hormone receptor (GHR) is expressed in many cells/tissues in the body. To investigate the specific metabolic effects of GH action in distinct tissues, several tissue-specific GHR gene disrupted or knockout (KO) mouse lines have been generated. Previously, we have described the effects of GHRKO in several known insulin sensitive tissues, namely liver, muscle and adipose tissue. In this review, we further explore and summarize the main findings of recently published GHRKO results in liver, adipocytes, intestine, bone, brain and heart.

KW - Adipose tissue

KW - Bone

KW - Brain

KW - Growth hormone receptor

KW - Heart

KW - IGF-I

KW - Intestine

KW - Liver

KW - Macrophages

KW - Tissue-specific

UR - https://www.scopus.com/pages/publications/85077396376

U2 - 10.1016/j.ghir.2019.12.004

DO - 10.1016/j.ghir.2019.12.004

M3 - Artículo

C2 - 31923746

AN - SCOPUS:85077396376

SN - 1096-6374

VL - 51

SP - 1

EP - 5

JO - Growth Hormone and IGF Research

JF - Growth Hormone and IGF Research

ER -

Tissue-specific disruption of the growth hormone receptor (GHR) in mice: An update

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this