Tracking sars-cov-2: Novel trends and diagnostic strategies

Linda P. Guaman-Bautista, Erick Moreta-Urbano, Claudia G. Oña-Arias, Marbel Torres-Arias, Nikolaos C. Kyriakidis, Koray Malcı, Nestor Jonguitud-Borrego, Leonardo Rios-Solis, Espiridion Ramos-Martinez, Andrés López-Cortés, Carlos Barba-Ostria

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

The COVID-19 pandemic has had an enormous impact on economies and health systems globally, therefore a top priority is the development of increasingly better diagnostic and surveillance alternatives to slow down the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In order to establish massive testing and contact tracing policies, it is crucial to have a clear view of the diagnostic options available and their principal advantages and drawbacks. Although classical molecular methods such as RT-qPCR are broadly used, diagnostic alternatives based on technologies such as LAMP, antigen, serological testing, or the application of novel technologies such as CRISPR-Cas for diagnostics, are also discussed. The present review also discusses the most important automation strategies employed to increase testing capability. Several serological-based diagnostic kits are presented, as well as novel nanotechnology-based diagnostic methods. In summary, this review provides a clear diagnostic landscape of the most relevant tools to track COVID-19.

Original languageEnglish
Article number1981
JournalDiagnostics
Volume11
Issue number11
DOIs
StatePublished - Nov 2021

Keywords

  • Antigen testing
  • Automation
  • COVID-19
  • CRISPR-based diagnostics
  • Nanotechnology-based diagnostics
  • Nucleic acid amplification test

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