A marked point process approach for identifying neural correlates of tics in Tourette Syndrome

Carlos A. Loza, Jonathan B. Shute, Jose C. Principe, Michael S. Okun, Aysegul Gunduz

Producción científica: Capítulo del libro/informe/acta de congresoContribución a la conferenciarevisión exhaustiva

3 Citas (Scopus)

Resumen

We propose a novel interpretation of local field potentials (LFP) based on a marked point process (MPP) framework that models relevant neuromodulations as shifted weighted versions of prototypical temporal patterns. Particularly, the MPP samples are categorized according to the well known oscillatory rhythms of the brain in an effort to elucidate spectrally specific behavioral correlates. The result is a transient model for LFP. We exploit data-driven techniques to fully estimate the model parameters with the added feature of exceptional temporal resolution of the resulting events. We utilize the learned features in the alpha and beta bands to assess correlations to tic events in patients with Tourette Syndrome (TS). The final results show stronger coupling between LFP recorded from the centromedian-paraficicular complex of the thalamus and the tic marks, in comparison to electrocorticogram (ECoG) recordings from the hand area of the primary motor cortex (M1) in terms of the area under the curve (AUC) of the receiver operating characteristic (ROC) curve.

Idioma originalInglés
Título de la publicación alojada2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtítulo de la publicación alojadaSmarter Technology for a Healthier World, EMBC 2017 - Proceedings
EditorialInstitute of Electrical and Electronics Engineers Inc.
Páginas4375-4378
Número de páginas4
ISBN (versión digital)9781509028092
DOI
EstadoPublicada - 13 sep. 2017
Publicado de forma externa
Evento39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017 - Jeju Island, República de Corea
Duración: 11 jul. 201715 jul. 2017

Serie de la publicación

NombreProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (versión impresa)1557-170X

Conferencia

Conferencia39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017
País/TerritorioRepública de Corea
CiudadJeju Island
Período11/07/1715/07/17

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