A new species of frog of the genus Pristimantis is described from the paramos of the Nudo de Cajanuma, Podocarpus National Park, on the border between the provinces of Loja and Zamora-Chinchipe, Ecuador. The new species is readily distinguished from all other species of Pristimantis by its large body size (snoutvent length: 50.0–50.5 mm in adult females, 34.7–42.5 mm in adult males), thick glandular skin, large warts on flanks, prominent glandular patches on head and legs, and dark brown dorsum. This new species is among the largest and stoutest Pristimantis frogs of the high Andes. It is only known from its type locality, where it occurs in paramo bambusoid meadows at elevations between 3300 and 3400 m. It is morphologically similar to Pristimantis erythros, P. farisorum, P. obmutescens, P. orcesi, P. racemus, P. simoterus, P. simoteriscus, and P. thymelensis. Notorious morphological characters present in this new species are thick glandular patches covering dorsum and limbs and porous skin texture, which are shared with P. erythros.