Acute appendicitis is one of the most common abdominal emergencies, even though most cases of appendicitis will be due to obstruction of the appendiceal lumen, in rare occasions and mostly due to poor sanitary conditions a parasitic infection may cause appendicitis. Entamoeba histolytica is a common parasite and has a broad clinical spectrum from an asymptomatic disease to a life-threatening condition. In rare occasions, trophozoites can invade the appendiceal wall causing appendicitis. Preoperative diagnosis of acute amebic appendicitis is usually difficult, yet surgical treatment as in non-amebic appendicitis is the treatment of choice. However, due to the increased rate of postoperative complications associated with acute amebic appendicitis, a course of nitroimidazoles, and increased awareness in basic sanitary measures is usually recommended. We present a case of a 29-year-old woman, she presented with abdominal pain and appendicitis was suspected. After successful surgery, pathology confirmed acute amebic appendicitis.