Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador

María Fernanda Zurita; Paúl A. Cárdenas; María Elena Sandoval; María Caridad Peña; Marco Fornasini; Nancy Flores; Marcia H. Monaco; Kirsten Berding; Sharon M. Donovan; Thomas Kuntz; Jack A. Gilbert; Manuel E. Baldeón

doi:10.1080/19490976.2019.1662260

Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador

María Fernanda Zurita, Paúl A. Cárdenas, María Elena Sandoval, María Caridad Peña, Marco Fornasini, Nancy Flores, Marcia H. Monaco, Kirsten Berding, Sharon M. Donovan, Thomas Kuntz, Jack A. Gilbert, Manuel E. Baldeón

Microbiología pregrado

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46 Citas (Scopus)

Resumen

Most studies on autism spectrum disorder (ASD) risk factors have been conducted in developed countries where ethnicity and environment are different than in developing countries. We compared nutritional status, immune response and microbiota composition in mestizo children with ASD with matched controls in Ecuador. Twenty-five cases and 35 controls were matched by age, sex and school location. The prevalence of under- and overweight was higher in children with ASD. Nutritional differences were accompanied by abnormal food habits and more frequent gastrointestinal symptoms in children with ASD. Also, greater serum concentrations of TGF-β1 were observed in children with ASD. Finally, there was greater alpha diversity and abundance of Bacteroides (2 OTUs), Akkermansia, Coprococcus and different species of Ruminococcus in ASD children.

Idioma original	Inglés
Páginas (desde-hasta)	453-464
Número de páginas	12
Publicación	Gut Microbes
Volumen	11
N.º	3
DOI	https://doi.org/10.1080/19490976.2019.1662260
Estado	Publicada - 3 may. 2020

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Zurita, M. F., Cárdenas, P. A., Sandoval, M. E., Peña, M. C., Fornasini, M., Flores, N., Monaco, M. H., Berding, K., Donovan, S. M., Kuntz, T., Gilbert, J. A., & Baldeón, M. E. (2020). Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador. Gut Microbes, 11(3), 453-464. https://doi.org/10.1080/19490976.2019.1662260

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title = "Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador",

abstract = "Most studies on autism spectrum disorder (ASD) risk factors have been conducted in developed countries where ethnicity and environment are different than in developing countries. We compared nutritional status, immune response and microbiota composition in mestizo children with ASD with matched controls in Ecuador. Twenty-five cases and 35 controls were matched by age, sex and school location. The prevalence of under- and overweight was higher in children with ASD. Nutritional differences were accompanied by abnormal food habits and more frequent gastrointestinal symptoms in children with ASD. Also, greater serum concentrations of TGF-β1 were observed in children with ASD. Finally, there was greater alpha diversity and abundance of Bacteroides (2 OTUs), Akkermansia, Coprococcus and different species of Ruminococcus in ASD children.",

keywords = "Autism spectrum disorder, Ecuador, behavior, immunity, microbiota, nutrition",

author = "Zurita, {Mar{\'i}a Fernanda} and C{\'a}rdenas, {Pa{\'u}l A.} and Sandoval, {Mar{\'i}a Elena} and Pe{\~n}a, {Mar{\'i}a Caridad} and Marco Fornasini and Nancy Flores and Monaco, {Marcia H.} and Kirsten Berding and Donovan, {Sharon M.} and Thomas Kuntz and Gilbert, {Jack A.} and Balde{\'o}n, {Manuel E.}",

note = "Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 Taylor & Francis Group, LLC.",

year = "2020",

month = may,

day = "3",

doi = "10.1080/19490976.2019.1662260",

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T1 - Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder

T2 - a case-control study in Ecuador

AU - Zurita, María Fernanda

AU - Cárdenas, Paúl A.

AU - Sandoval, María Elena

AU - Peña, María Caridad

AU - Fornasini, Marco

AU - Flores, Nancy

AU - Monaco, Marcia H.

AU - Berding, Kirsten

AU - Donovan, Sharon M.

AU - Kuntz, Thomas

AU - Gilbert, Jack A.

AU - Baldeón, Manuel E.

PY - 2020/5/3

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AB - Most studies on autism spectrum disorder (ASD) risk factors have been conducted in developed countries where ethnicity and environment are different than in developing countries. We compared nutritional status, immune response and microbiota composition in mestizo children with ASD with matched controls in Ecuador. Twenty-five cases and 35 controls were matched by age, sex and school location. The prevalence of under- and overweight was higher in children with ASD. Nutritional differences were accompanied by abnormal food habits and more frequent gastrointestinal symptoms in children with ASD. Also, greater serum concentrations of TGF-β1 were observed in children with ASD. Finally, there was greater alpha diversity and abundance of Bacteroides (2 OTUs), Akkermansia, Coprococcus and different species of Ruminococcus in ASD children.

KW - Autism spectrum disorder

KW - Ecuador

KW - behavior

KW - immunity

KW - microbiota

KW - nutrition

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U2 - 10.1080/19490976.2019.1662260

DO - 10.1080/19490976.2019.1662260

M3 - Artículo

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AN - SCOPUS:85073943227

SN - 1949-0976

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JO - Gut Microbes

JF - Gut Microbes

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ER -

Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador

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