In 2020, Ecuadorian politics was not only constrained by the COVID-19 pandemic, but also stirred by political instability and an intense online electoral campaign. In this article, we outline the Ecuadorian economic, social, and political context from February 2020 to February 2021. Then, we explore the core measures and overall impacts of the COVID-19 on Ecuadorian politics. We also present the main institutional and policy changes, bearing in mind that 2020 was the last year of Lenín Moreno’s presidential term. In addition, this article examines the latest electoral reform and the main issues of the electoral campaign, as well as the key results of the national and Andean elections of February 2021.