Biological magnetic cellular spheroids as building blocks for tissue engineering

Brandon Mattix, Timothy R. Olsen, Yu Gu, Megan Casco, Austin Herbst, Dan T. Simionescu, Richard P. Visconti, Konstantin G. Kornev, Frank Alexis

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

50 Citas (Scopus)


Magnetic nanoparticles (MNPs), primarily iron oxide nanoparticles, have been incorporated into cellular spheroids to allow for magnetic manipulation into desired shapes, patterns and 3-D tissue constructs using magnetic forces. However, the direct and long-term interaction of iron oxide nanoparticles with cells and biological systems can induce adverse effects on cell viability, phenotype and function, and remain a critical concern. Here we report the preparation of biological magnetic cellular spheroids containing magnetoferritin, a biological MNP, capable of serving as a biological alternative to iron oxide magnetic cellular spheroids as tissue engineered building blocks. Magnetoferritin NPs were incorporated into 3-D cellular spheroids with no adverse effects on cell viability up to 1 week. Additionally, cellular spheroids containing magnetoferritin NPs were magnetically patterned and fused into a tissue ring to demonstrate its potential for tissue engineering applications. These results present a biological approach that can serve as an alternative to the commonly used iron oxide magnetic cellular spheroids, which often require complex surface modifications of iron oxide NPs to reduce the adverse effects on cells.

Idioma originalInglés
Páginas (desde-hasta)623-629
Número de páginas7
PublicaciónActa Biomaterialia
EstadoPublicada - feb. 2014
Publicado de forma externa


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