TY - JOUR
T1 - Biomedical applications of hydroxyapatite nanoparticles
AU - Loo, S. C.J.
AU - Moore, T.
AU - Banik, B.
AU - Alexis, F.
PY - 2010
Y1 - 2010
N2 - Nanotechnologies have the potential to improve current disease diagnosis due to their ability to circulate in the blood and distribute in the body to image tissues and cells or therapeutical applications to deliver a payload. Among nanoparticles with different materials composition, inorganic nanoparticles composed of calcium phosphate have numerous advantages including ease of synthesis, control of physico-chemical properties, strong interactions with their payload, and biocompatibility. In this review we discuss the different routes of synthesis of calcium phosphate nanoparticles, novel systems, strategies to load agents, biostability and cytotoxicity, biodistribution and pharmacokinetics, bio-imaging and therapeutical applications.
AB - Nanotechnologies have the potential to improve current disease diagnosis due to their ability to circulate in the blood and distribute in the body to image tissues and cells or therapeutical applications to deliver a payload. Among nanoparticles with different materials composition, inorganic nanoparticles composed of calcium phosphate have numerous advantages including ease of synthesis, control of physico-chemical properties, strong interactions with their payload, and biocompatibility. In this review we discuss the different routes of synthesis of calcium phosphate nanoparticles, novel systems, strategies to load agents, biostability and cytotoxicity, biodistribution and pharmacokinetics, bio-imaging and therapeutical applications.
KW - Bio-imaging
KW - Calcium-phosphate
KW - Drug delivery
KW - Gene-delivery
KW - Inorganic nanoparticles
KW - Particulate systems
UR - http://www.scopus.com/inward/record.url?scp=77953735861&partnerID=8YFLogxK
U2 - 10.2174/138920110791233343
DO - 10.2174/138920110791233343
M3 - Artículo
C2 - 20199383
AN - SCOPUS:77953735861
SN - 1389-2010
VL - 11
SP - 333
EP - 342
JO - Current Pharmaceutical Biotechnology
JF - Current Pharmaceutical Biotechnology
IS - 4
ER -