Clopidogrel resistance in extremely high cardiovascular risk patients with genotype CYP2C19

Liliana Cárdenas; Ali Aymen Abdullah; Gabriela Jaramillo; Paúl Cárdenas; Gabriela Gálvez; Fernando Hidalgo

doi:10.63600/VDCJET22

Clopidogrel resistance in extremely high cardiovascular risk patients with genotype CYP2C19

Título traducido de la contribución: Resistencia al clopidogrel en pacientes con extremado alto riesgo cardiovascular con genotipo CYP2C19

Liliana Cárdenas
, Ali Aymen Abdullah^*
, Gabriela Jaramillo
, Paúl Cárdenas
, Gabriela Gálvez
, Fernando Hidalgo

^*Autor correspondiente de este trabajo

Hospital Eugenio Espejo

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

2 Citas (Scopus)

Resumen

Identifying risk factors is of utmost importance in patients with cardiovascular risk, even more so in those with extremely high risk, who still present with complications despite receiving treatment as secondary prevention. We hypothesized that patients with very high cardiovascular risk would have genetic resistance to the antiplatelet agent clopidogrel. We performed a cross-sectional descriptive study that included 58 patients with the CYP2C19 genotype in the coronary care unit of the hospital, who were divided into two groups: resistant and non-resistant to therapy. We confirmed that patients in extremely high cardiovascular risk had more genetic resistance to clopidogrel, which caused secondary prevention failure, so they would benefit from individualizing antiplatelet therapy.

Título traducido de la contribución	Resistencia al clopidogrel en pacientes con extremado alto riesgo cardiovascular con genotipo CYP2C19
Idioma original	Inglés
Páginas (desde-hasta)	134-137
Número de páginas	4
Publicación	Revista de la Federacion Argentina de Cardiologia
Volumen	52
N.º	3
DOI	https://doi.org/10.63600/VDCJET22
Estado	Publicada - 28 sep. 2023

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abstract = "Identifying risk factors is of utmost importance in patients with cardiovascular risk, even more so in those with extremely high risk, who still present with complications despite receiving treatment as secondary prevention. We hypothesized that patients with very high cardiovascular risk would have genetic resistance to the antiplatelet agent clopidogrel. We performed a cross-sectional descriptive study that included 58 patients with the CYP2C19 genotype in the coronary care unit of the hospital, who were divided into two groups: resistant and non-resistant to therapy. We confirmed that patients in extremely high cardiovascular risk had more genetic resistance to clopidogrel, which caused secondary prevention failure, so they would benefit from individualizing antiplatelet therapy.",

keywords = "Cytochrome P-450 CYP2C19, cardiovascular disease, clopidogrel, drug resistance, platelet antiaggregants",

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T1 - Clopidogrel resistance in extremely high cardiovascular risk patients with genotype CYP2C19

AU - Cárdenas, Liliana

AU - Abdullah, Ali Aymen

AU - Jaramillo, Gabriela

AU - Cárdenas, Paúl

AU - Gálvez, Gabriela

AU - Hidalgo, Fernando

PY - 2023/9/28

Y1 - 2023/9/28

N2 - Identifying risk factors is of utmost importance in patients with cardiovascular risk, even more so in those with extremely high risk, who still present with complications despite receiving treatment as secondary prevention. We hypothesized that patients with very high cardiovascular risk would have genetic resistance to the antiplatelet agent clopidogrel. We performed a cross-sectional descriptive study that included 58 patients with the CYP2C19 genotype in the coronary care unit of the hospital, who were divided into two groups: resistant and non-resistant to therapy. We confirmed that patients in extremely high cardiovascular risk had more genetic resistance to clopidogrel, which caused secondary prevention failure, so they would benefit from individualizing antiplatelet therapy.

AB - Identifying risk factors is of utmost importance in patients with cardiovascular risk, even more so in those with extremely high risk, who still present with complications despite receiving treatment as secondary prevention. We hypothesized that patients with very high cardiovascular risk would have genetic resistance to the antiplatelet agent clopidogrel. We performed a cross-sectional descriptive study that included 58 patients with the CYP2C19 genotype in the coronary care unit of the hospital, who were divided into two groups: resistant and non-resistant to therapy. We confirmed that patients in extremely high cardiovascular risk had more genetic resistance to clopidogrel, which caused secondary prevention failure, so they would benefit from individualizing antiplatelet therapy.

KW - Cytochrome P-450 CYP2C19

KW - cardiovascular disease

KW - clopidogrel

KW - drug resistance

KW - platelet antiaggregants

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DO - 10.63600/VDCJET22

M3 - Artículo

AN - SCOPUS:105018854883

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JF - Revista de la Federacion Argentina de Cardiologia

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ER -

Clopidogrel resistance in extremely high cardiovascular risk patients with genotype CYP2C19

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