Co-delivery of hydrophobic and hydrophilic drugsfrom nanoparticle-aptamer bioconjugates

Liangfang Zhang, Aleksandar F. Radovic-Moreno, Frank Alexis, Frank X. Gu, Pamela A. Basto, Vaishali Bagalkot, Sangyong Jon, Robert S. Langer, Omid C. Farokhzad

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

242 Citas (Scopus)

Resumen

(Figure Presented) Herein we report a novel targeted drug delivery system consisting of nanoparticle-aptamer bioconjugates,which can carry both hydrophobic and hydrophilic chemotherapeutic drugs simultaneously, and deliver them selectively in a targeted and temporally distinct manner. This work provides a robust platform for targeted co-delivery of chemotherapeutic agents with the hope of both leveraging the synergistic effects of multiple drugs and also potentially suppressing the likelihood of drug resistance by the treated tissues.

Idioma originalInglés
Páginas (desde-hasta)1268-1271
Número de páginas4
PublicaciónChemMedChem
Volumen2
N.º9
DOI
EstadoPublicada - 10 sep. 2007
Publicado de forma externa

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