Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia

Enrique Teran, Isabel Hernandez, Belen Nieto, Rosio Tavara, Juan Emilio Ocampo, Andres Calle

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

78 Citas (Scopus)

Resumen

Objective: To assess whether supplementation with Coenzyme Q10 (CoQ10) during pregnancy reduces the risk of pre-eclampsia. Methods: Women at increased risk of pre-eclampsia were enrolled in a randomized, double-blind, placebo-controlled trial. Women were assigned to receive 200 mg of CoQ10 or placebo daily from 20 weeks of pregnancy until delivery. The primary outcome was rate of pre-eclampsia. Statistical analyses were by intention-to-treat. Results: Of the 235 women enrolled in the trial, 118 were randomized to receive CoQ10 and 117 received a placebo. A total of 197 (83.8%) women were followed-up. The overall rate of pre-eclampsia was 20% (n = 47). Thirty women (25.6%) in the placebo group developed pre-eclampsia compared with 17 women (14.4%) in the CoQ10 group, and this reduction was significant (P = 0.035) (relative risk [RR] 0.56; 95% confidence interval [CI], 0.33-0.96). Conclusion: Supplementation with CoQ10 reduces the risk of developing pre-eclampsia in women at risk for the condition.

Idioma originalInglés
Páginas (desde-hasta)43-45
Número de páginas3
PublicaciónInternational Journal of Gynecology and Obstetrics
Volumen105
N.º1
DOI
EstadoPublicada - abr. 2009
Publicado de forma externa

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