Computer-aided drug design methodologies toward the design of anti-hepatitis C agents

Alejandro Speck-Planche, M. Natália D.S. Cordeiro

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

24 Citas (Scopus)

Resumen

Hepatitis C constitutes an infectious disease that causes severe damages to the liver, and is caused by hepatitis C virus. There is no vaccine against this type of disease and the number of people infected continues to grow worldwide. The anti-viral therapy which is currently used is a mixture of interferon alpha-2a with ribavirin, but approximately half of the patients do not respond to therapy. Therefore, it is necessary to search for new compounds with anti-hepatitis C activity. Computer-aided drug design methodologies have been vital in the discovery of candidates to drugs. This review is dedicated to the role of computer-aided drug design methodologies for the development of new anti-hepatitis C agents. In addition, we introduce a QSAR model based on substructural approaches in order to model the anti-hepatitis C activity in vivo.

Idioma originalInglés
Páginas (desde-hasta)802-813
Número de páginas12
PublicaciónCurrent Topics in Medicinal Chemistry
Volumen12
N.º8
DOI
EstadoPublicada - abr. 2012
Publicado de forma externa

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