Controversy in clinical endocrinology: Reclassification of insulin-like growth factor I production and action disorders

Arlan L. Rosenbloom, Jaime Guevara-Aguirre

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

13 Citas (Scopus)

Resumen

Context: The need for the least ambiguous terminology for disorders affecting IGF-I production and action has become necessary with identification of defects at various steps in the GH-IGF-I axis and the promotion of new indications for and modalities of growth therapy. No generally agreed-upon or consensus-derived classification exists. Objective: Our objective was to designate all disorders affecting IGF-I production and action by their discrete location, as is already done with the defects in pituitary differentiation factors, avoiding imprecise and ambiguous terminology. Conclusions: We propose a pragmatic classification that is a precise listing of specific disorders sequentially following the GH-IGF-I axis, using their accepted designations, and the abolition of nonspecific or ambiguous terminology. This concept permits ready insertion of new discoveries.

Idioma originalInglés
Páginas (desde-hasta)4232-4234
Número de páginas3
PublicaciónJournal of Clinical Endocrinology and Metabolism
Volumen91
N.º11
DOI
EstadoPublicada - nov. 2006
Publicado de forma externa

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