Disordered microbial communities in asthmatic airways

Markus Hilty, Conor Burke, Helder Pedro, Paul Cardenas, Andy Bush, Cara Bossley, Jane Davies, Aaron Ervine, Len Poulter, Lior Pachter, Miriam F. Moffatt, William O.C. Cookson

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

1325 Citas (Scopus)

Resumen

Background: A rich microbial environment in infancy protects against asthma [1,2] and infections precipitate asthma exacerbations [3]. We compared the airway microbiota at three levels in adult patients with asthma, the related condition of COPD, and controls. We also studied bronchial lavage from asthmatic children and controls. Principal Findings: We identified 5,054 16S rRNA bacterial sequences from 43 subjects, detecting > 70% of species present. The bronchial tree was not sterile, and contained a mean of 2,000 bacterial genomes per cm2 surface sampled. Pathogenic Proteobacteria, particularly Haemophilus spp., were much more frequent in bronchi of adult asthmatics or patients with COPD than controls. We found similar highly significant increases in Proteobacteria in asthmatic children. Conversely, Bacteroidetes, particularly Prevotella spp., were more frequent in controls than adult or child asthmatics or COPD patients. Significance: The results show the bronchial tree to contain a characteristic microbiota, and suggest that this microbiota is disturbed in asthmatic airways.

Idioma originalInglés
Número de artículoe8578
PublicaciónPLoS ONE
Volumen5
N.º1
DOI
EstadoPublicada - 5 ene. 2010
Publicado de forma externa

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