TY - JOUR
T1 - Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues
AU - Duran-Ortiz, Silvana
AU - Noboa, Vanessa
AU - Kopchick, John J.
N1 - Publisher Copyright:
© 2017
PY - 2018/2
Y1 - 2018/2
N2 - To elucidate whether a specific tissue is responsible for the beneficial health and longevity phenotype seen in growth hormone (GH) receptor (R) knockout (GHRKO) mice, the GHR gene was disrupted specifically in insulin sensitive tissues; namely, liver, adipose, and muscle. Furthermore, to investigate if the health- and life-span effects seen in the germline GHRKO mice were replicated when GH action was ablated after puberty; young, adult onset GHRKO mice were produced and characterized. In this review, we summarized the main findings derived from these mouse lines.
AB - To elucidate whether a specific tissue is responsible for the beneficial health and longevity phenotype seen in growth hormone (GH) receptor (R) knockout (GHRKO) mice, the GHR gene was disrupted specifically in insulin sensitive tissues; namely, liver, adipose, and muscle. Furthermore, to investigate if the health- and life-span effects seen in the germline GHRKO mice were replicated when GH action was ablated after puberty; young, adult onset GHRKO mice were produced and characterized. In this review, we summarized the main findings derived from these mouse lines.
KW - Adipose tissue
KW - Growth hormone receptor
KW - IGF-I
KW - Liver
KW - Muscle
UR - http://www.scopus.com/inward/record.url?scp=85036566589&partnerID=8YFLogxK
U2 - 10.1016/j.ghir.2017.11.003
DO - 10.1016/j.ghir.2017.11.003
M3 - Artículo
C2 - 29198419
AN - SCOPUS:85036566589
SN - 1096-6374
VL - 38
SP - 3
EP - 7
JO - Growth Hormone and IGF Research
JF - Growth Hormone and IGF Research
ER -
