Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues

Silvana Duran-Ortiz, Vanessa Noboa, John J. Kopchick

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

15 Citas (Scopus)

Resumen

To elucidate whether a specific tissue is responsible for the beneficial health and longevity phenotype seen in growth hormone (GH) receptor (R) knockout (GHRKO) mice, the GHR gene was disrupted specifically in insulin sensitive tissues; namely, liver, adipose, and muscle. Furthermore, to investigate if the health- and life-span effects seen in the germline GHRKO mice were replicated when GH action was ablated after puberty; young, adult onset GHRKO mice were produced and characterized. In this review, we summarized the main findings derived from these mouse lines.

Idioma originalInglés
Páginas (desde-hasta)3-7
Número de páginas5
PublicaciónGrowth Hormone and IGF Research
Volumen38
DOI
EstadoPublicada - feb. 2018

Huella

Profundice en los temas de investigación de 'Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues'. En conjunto forman una huella única.

Citar esto