Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues

Silvana Duran-Ortiz; Vanessa Noboa; John J. Kopchick

doi:10.1016/j.ghir.2017.11.003

Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues

Silvana Duran-Ortiz
, Vanessa Noboa
, John J. Kopchick^*

^*Autor correspondiente de este trabajo

Medicina

Ohio University
College of Arts and Sciences
Molecular and Cellular Biology Program
Ohio University

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

16 Citas (Scopus)

Resumen

To elucidate whether a specific tissue is responsible for the beneficial health and longevity phenotype seen in growth hormone (GH) receptor (R) knockout (GHRKO) mice, the GHR gene was disrupted specifically in insulin sensitive tissues; namely, liver, adipose, and muscle. Furthermore, to investigate if the health- and life-span effects seen in the germline GHRKO mice were replicated when GH action was ablated after puberty; young, adult onset GHRKO mice were produced and characterized. In this review, we summarized the main findings derived from these mouse lines.

Idioma original	Inglés
Páginas (desde-hasta)	3-7
Número de páginas	5
Publicación	Growth Hormone and IGF Research
Volumen	38
DOI	https://doi.org/10.1016/j.ghir.2017.11.003
Estado	Publicada - feb. 2018

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title = "Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues",

abstract = "To elucidate whether a specific tissue is responsible for the beneficial health and longevity phenotype seen in growth hormone (GH) receptor (R) knockout (GHRKO) mice, the GHR gene was disrupted specifically in insulin sensitive tissues; namely, liver, adipose, and muscle. Furthermore, to investigate if the health- and life-span effects seen in the germline GHRKO mice were replicated when GH action was ablated after puberty; young, adult onset GHRKO mice were produced and characterized. In this review, we summarized the main findings derived from these mouse lines.",

keywords = "Adipose tissue, Growth hormone receptor, IGF-I, Liver, Muscle",

author = "Silvana Duran-Ortiz and Vanessa Noboa and Kopchick, \{John J.\}",

note = "Publisher Copyright: {\textcopyright} 2017",

year = "2018",

month = feb,

doi = "10.1016/j.ghir.2017.11.003",

language = "Ingl{\'e}s",

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journal = "Growth Hormone and IGF Research",

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TY - JOUR

T1 - Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues

AU - Duran-Ortiz, Silvana

AU - Noboa, Vanessa

AU - Kopchick, John J.

PY - 2018/2

Y1 - 2018/2

N2 - To elucidate whether a specific tissue is responsible for the beneficial health and longevity phenotype seen in growth hormone (GH) receptor (R) knockout (GHRKO) mice, the GHR gene was disrupted specifically in insulin sensitive tissues; namely, liver, adipose, and muscle. Furthermore, to investigate if the health- and life-span effects seen in the germline GHRKO mice were replicated when GH action was ablated after puberty; young, adult onset GHRKO mice were produced and characterized. In this review, we summarized the main findings derived from these mouse lines.

AB - To elucidate whether a specific tissue is responsible for the beneficial health and longevity phenotype seen in growth hormone (GH) receptor (R) knockout (GHRKO) mice, the GHR gene was disrupted specifically in insulin sensitive tissues; namely, liver, adipose, and muscle. Furthermore, to investigate if the health- and life-span effects seen in the germline GHRKO mice were replicated when GH action was ablated after puberty; young, adult onset GHRKO mice were produced and characterized. In this review, we summarized the main findings derived from these mouse lines.

KW - Adipose tissue

KW - Growth hormone receptor

KW - IGF-I

KW - Liver

KW - Muscle

UR - https://www.scopus.com/pages/publications/85036566589

U2 - 10.1016/j.ghir.2017.11.003

DO - 10.1016/j.ghir.2017.11.003

M3 - Artículo

C2 - 29198419

AN - SCOPUS:85036566589

SN - 1096-6374

VL - 38

SP - 3

EP - 7

JO - Growth Hormone and IGF Research

JF - Growth Hormone and IGF Research

ER -

Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues

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