Endogenous origin of Pseudomonas aeruginosa infecting hospitalized patients in Ecuador

Gabriela Vasco; Mishell Achig; Belén Prado-Vivar; Maritza Páez; Franklin Espinosa; Evelyn Espinoza; Danny Quinancela; Paul Cardenas; Gabriel Trueba

doi:10.1016/j.infpip.2023.100331

Endogenous origin of Pseudomonas aeruginosa infecting hospitalized patients in Ecuador

Gabriela Vasco, Mishell Achig, Belén Prado-Vivar, Maritza Páez, Franklin Espinosa, Evelyn Espinoza, Danny Quinancela, Paul Cardenas, Gabriel Trueba

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Resumen

Recent evidence suggests that Pseudomonas aeruginosa, a bacterium that has the ability to cause deadly infections in hospitalized patients, could originate in the patient's own flora. We employed the Oxford Nanopore platform to obtain whole genome sequences (WGS) from clinical and rectal screen P. aeruginosa strains belonging to 15 patients from two hospitals. Our study found evidence that clinical and rectal isolates were clonal, with some evidence suggesting that the infecting strain was present in the patient's intestine at the time of admission, ruling out hospital acquisition. The use of WGS analysis is crucial to detect alternative sources of P. aeruginosa to develop new preventive measures against these serious infections.

Idioma original	Inglés
Número de artículo	100331
Publicación	Infection Prevention in Practice
Volumen	6
N.º	1
DOI	https://doi.org/10.1016/j.infpip.2023.100331
Estado	Publicada - mar. 2024

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title = "Endogenous origin of Pseudomonas aeruginosa infecting hospitalized patients in Ecuador",

abstract = "Recent evidence suggests that Pseudomonas aeruginosa, a bacterium that has the ability to cause deadly infections in hospitalized patients, could originate in the patient's own flora. We employed the Oxford Nanopore platform to obtain whole genome sequences (WGS) from clinical and rectal screen P. aeruginosa strains belonging to 15 patients from two hospitals. Our study found evidence that clinical and rectal isolates were clonal, with some evidence suggesting that the infecting strain was present in the patient's intestine at the time of admission, ruling out hospital acquisition. The use of WGS analysis is crucial to detect alternative sources of P. aeruginosa to develop new preventive measures against these serious infections.",

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AU - Vasco, Gabriela

AU - Achig, Mishell

AU - Prado-Vivar, Belén

AU - Páez, Maritza

AU - Espinosa, Franklin

AU - Espinoza, Evelyn

AU - Quinancela, Danny

AU - Cardenas, Paul

AU - Trueba, Gabriel

PY - 2024/3

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N2 - Recent evidence suggests that Pseudomonas aeruginosa, a bacterium that has the ability to cause deadly infections in hospitalized patients, could originate in the patient's own flora. We employed the Oxford Nanopore platform to obtain whole genome sequences (WGS) from clinical and rectal screen P. aeruginosa strains belonging to 15 patients from two hospitals. Our study found evidence that clinical and rectal isolates were clonal, with some evidence suggesting that the infecting strain was present in the patient's intestine at the time of admission, ruling out hospital acquisition. The use of WGS analysis is crucial to detect alternative sources of P. aeruginosa to develop new preventive measures against these serious infections.

AB - Recent evidence suggests that Pseudomonas aeruginosa, a bacterium that has the ability to cause deadly infections in hospitalized patients, could originate in the patient's own flora. We employed the Oxford Nanopore platform to obtain whole genome sequences (WGS) from clinical and rectal screen P. aeruginosa strains belonging to 15 patients from two hospitals. Our study found evidence that clinical and rectal isolates were clonal, with some evidence suggesting that the infecting strain was present in the patient's intestine at the time of admission, ruling out hospital acquisition. The use of WGS analysis is crucial to detect alternative sources of P. aeruginosa to develop new preventive measures against these serious infections.

KW - Acute infection

KW - Colonization

KW - Nosocomial

KW - Pseudomonas aeruginosa

KW - Whole genome sequencing

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DO - 10.1016/j.infpip.2023.100331

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Endogenous origin of Pseudomonas aeruginosa infecting hospitalized patients in Ecuador

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