Endogenous origin of Pseudomonas aeruginosa infecting hospitalized patients in Ecuador

Gabriela Vasco, Mishell Achig, Belén Prado-Vivar, Maritza Páez, Franklin Espinosa, Evelyn Espinoza, Danny Quinancela, Paul Cardenas, Gabriel Trueba

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Recent evidence suggests that Pseudomonas aeruginosa, a bacterium that has the ability to cause deadly infections in hospitalized patients, could originate in the patient's own flora. We employed the Oxford Nanopore platform to obtain whole genome sequences (WGS) from clinical and rectal screen P. aeruginosa strains belonging to 15 patients from two hospitals. Our study found evidence that clinical and rectal isolates were clonal, with some evidence suggesting that the infecting strain was present in the patient's intestine at the time of admission, ruling out hospital acquisition. The use of WGS analysis is crucial to detect alternative sources of P. aeruginosa to develop new preventive measures against these serious infections.

Idioma originalInglés
Número de artículo100331
PublicaciónInfection Prevention in Practice
Volumen6
N.º1
DOI
EstadoPublicada - mar. 2024

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