Erythrocyte folate content and serum folic acid and homocysteine levels in preeclamptic primigravidae teenagers living at high altitude

Pablo Yanez, Carlos J. Vásquez, Luis Rodas, Augusto Durán, Peter Chedraui, Kim H. Liem, Faustino R. Pérez-López, Enrique Teran

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

6 Citas (Scopus)

Resumen

Objective: To measure erythrocyte folate content and serum folic acid and homocysteine (Hcy) levels in preeclamptic primigravidae teenagers living at high altitude. Methods: Measured analytes were compared to those found in normal teen controls. Results: Teenagers complicated with preeclampsia displayed significantly lower hematocrit and erythrocyte folic acid levels with higher serum Hcy levels as compared to controls (36.40 ± 4.90 vs. 38.99 ± 2.89 %, 493.80 ± 237.30 vs. 589.90 ± 210.60 ng/mL, and 7.29 ± 2.52 vs. 5.97 ± 1.41 μmol/L, respectively, p < 0.05). There was a non-significant trend for lower serum folic acid levels among preeclampsia teenagers. Serum and erythrocyte folic acid levels positively correlated in preeclampsia teenagers, and levels of both analytes inversely correlated with Hcy levels. Conclusion: This pilot study found that teenagers complicated with preeclampsia living at higher altitude displayed lower erythrocyte folate content in addition to higher serum Hcy levels. More research is warranted to determine the clinical implications of these findings.

Idioma originalInglés
Páginas (desde-hasta)1011-1015
Número de páginas5
PublicaciónArchives of Gynecology and Obstetrics
Volumen288
N.º5
DOI
EstadoPublicada - nov. 2013

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