@article{069c40e9831b4b9cab37dec2e9edc9a8,
title = "Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic",
abstract = "We present evidence for multiple independent origins of recombinant SARS-CoV-2 viruses sampled from late 2020 and early 2021 in the United Kingdom. Their genomes carry single-nucleotide polymorphisms and deletions that are characteristic of the B.1.1.7 variant of concern but lack the full complement of lineage-defining mutations. Instead, the remainder of their genomes share contiguous genetic variation with non-B.1.1.7 viruses circulating in the same geographic area at the same time as the recombinants. In four instances, there was evidence for onward transmission of a recombinant-origin virus, including one transmission cluster of 45 sequenced cases over the course of 2 months. The inferred genomic locations of recombination breakpoints suggest that every community-transmitted recombinant virus inherited its spike region from a B.1.1.7 parental virus, consistent with a transmission advantage for B.1.1.7's set of mutations.",
keywords = "B.1.1.7, SARS-CoV-2, evolution, genomic epidemiology, genomics, recombination, variants",
author = "{The COVID-19 Genomics UK (COG-UK) Consortium} and {Sanger Covid Team} and Ben Jackson and Boni, {Maciej F.} and Bull, {Matthew J.} and Amy Colleran and Colquhoun, {Rachel M.} and Darby, {Alistair C.} and Sam Haldenby and Verity Hill and Anita Lucaci and McCrone, {John T.} and Nicholls, {Samuel M.} and {\'A}ine O{\textquoteright}Toole and Nicole Pacchiarini and Radoslaw Poplawski and Emily Scher and Flora Todd and Webster, {Hermione J.} and Mark Whitehead and Claudia Wierzbicki and Loman, {Nicholas J.} and Connor, {Thomas R.} and Robertson, {David L.} and Pybus, {Oliver G.} and Andrew Rambaut and Robson, {Samuel C.} and Tanya Golubchi and {Martinez Nunez}, {Rocio T.} and Catherine Ludden and Sally Corden and Ian Johnston and David Bonsall and Smith, {Colin P.} and Awan, {Ali R.} and Giselda Bucca and {Estee Torok}, M. and Kordo Saeed and Prieto, {Jacqui A.} and Jackson, {David K.} and Hamilton, {William L.} and Snell, {Luke B.} and Catherine Moore and Harrison, {Ewan M.} and Sonia Goncalves and Jackson, {Leigh M.} and Goodfellow, {Ian G.} and Fairley, {Derek J.} and Loose, {Matthew W.} and Joanne Watkins and Rich Livett and Bernardo Gutierrez",
note = "Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2021",
month = sep,
day = "30",
doi = "10.1016/j.cell.2021.08.014",
language = "Ingl{\'e}s",
volume = "184",
pages = "5179--5188.e8",
journal = "Cell",
issn = "0092-8674",
number = "20",
}