TY - JOUR
T1 - Graphene quantum dots decorated with imatinib for leukemia treatment
AU - Felix, Daniele Mendes
AU - Rebelo Alencar, Luciana Magalhães
AU - Duarte de Menezes, Frederico
AU - Midlej, Victor do Valle Pereira
AU - Aguiar, Lorayne
AU - Gemini Piperni, Sara
AU - Zhang, Jian
AU - Liu, Yin
AU - Ricci-Junior, Eduardo
AU - Alexis, Frank
AU - Junior, Severino Alves
AU - Zhu, Lin
AU - Santos-Oliveira, Ralph
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2021/2
Y1 - 2021/2
N2 - The use of graphene quantum dots as biomedical device and drug delivery system has been increasing. This nano-platform of pure carbon has showed unique properties and showed to be safe for human use. The imatinib is a molecule designed to specifically inhibit the tyrosine kinase, used for leukemia treatment. In this study, we successfully decorated the graphene quantum dots (GQDs@imatinb) by a carbodiimide crosslinking reaction. The GQDs@imatinb were characterized by FTIR and AFM. The nanoparticles' in vitro behaviors were evaluated by cellular trafficking (internalization) assay and cell viability and apoptosis assays in various cancer cell lines, including suspension (leukemia) cells and adherent cancer cells. The results showed that the incorporation of the imatinib on the surface of the graphene quantum dots did not change the nanoparticles’ morphology and properties. The GQDs@imatinb could be efficiently internalized and kill cancer cells via the induction of apoptosis. The data indicated that the prepared GQDs@imatinb might be a great drug nano-platform for cancer, particularly leukemia treatments.
AB - The use of graphene quantum dots as biomedical device and drug delivery system has been increasing. This nano-platform of pure carbon has showed unique properties and showed to be safe for human use. The imatinib is a molecule designed to specifically inhibit the tyrosine kinase, used for leukemia treatment. In this study, we successfully decorated the graphene quantum dots (GQDs@imatinb) by a carbodiimide crosslinking reaction. The GQDs@imatinb were characterized by FTIR and AFM. The nanoparticles' in vitro behaviors were evaluated by cellular trafficking (internalization) assay and cell viability and apoptosis assays in various cancer cell lines, including suspension (leukemia) cells and adherent cancer cells. The results showed that the incorporation of the imatinib on the surface of the graphene quantum dots did not change the nanoparticles’ morphology and properties. The GQDs@imatinb could be efficiently internalized and kill cancer cells via the induction of apoptosis. The data indicated that the prepared GQDs@imatinb might be a great drug nano-platform for cancer, particularly leukemia treatments.
KW - Biomedical device
KW - Drug delivery
KW - Graphene quantum dot
KW - Nanoparticle
KW - Smart material
UR - http://www.scopus.com/inward/record.url?scp=85092260960&partnerID=8YFLogxK
U2 - 10.1016/j.jddst.2020.102117
DO - 10.1016/j.jddst.2020.102117
M3 - Artículo
AN - SCOPUS:85092260960
SN - 1773-2247
VL - 61
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
M1 - 102117
ER -
