Growth in growth hormone insensitivity

Arlan L. Rosenbloom; Jaime Guevara-Aguirre; Ron G. Rosenfeld; Brad H. Pollock

doi:10.1016/1043-2760(94)P3205-L

Growth in growth hormone insensitivity

Arlan L. Rosenbloom, Jaime Guevara-Aguirre, Ron G. Rosenfeld, Brad H. Pollock

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

34 Citas (Scopus)

Resumen

Primary GH insensitivity due to GH receptor deficiency (GHRD) provides a model for studying the discrete effects of severe IGF-I deficiency on growth and body composition. Growth failure in utero is doubtful, but postpartum growth proceeds at rates that result in adult statures 4-12 standard deviations (SDs) below the normal mean. Wide variability in statural effect, even in a genetically homogeneous population, is partly explained by correlation of SD score with biochemical measures of GH effect (IGF-I, IGF-II, and IGFBP-3). Growth and changes in body composition (decreased fat/lean) in patients with GHRD in response to exogenous IGF-I indicate that direct local effects of GH are not necessary for these responses.

Idioma original	Inglés
Páginas (desde-hasta)	296-303
Número de páginas	8
Publicación	Trends in Endocrinology and Metabolism
Volumen	5
N.º	7
DOI	https://doi.org/10.1016/1043-2760(94)P3205-L
Estado	Publicada - sep. 1994
Publicado de forma externa	Sí

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abstract = "Primary GH insensitivity due to GH receptor deficiency (GHRD) provides a model for studying the discrete effects of severe IGF-I deficiency on growth and body composition. Growth failure in utero is doubtful, but postpartum growth proceeds at rates that result in adult statures 4-12 standard deviations (SDs) below the normal mean. Wide variability in statural effect, even in a genetically homogeneous population, is partly explained by correlation of SD score with biochemical measures of GH effect (IGF-I, IGF-II, and IGFBP-3). Growth and changes in body composition (decreased fat/lean) in patients with GHRD in response to exogenous IGF-I indicate that direct local effects of GH are not necessary for these responses.",

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AU - Rosenbloom, Arlan L.

AU - Guevara-Aguirre, Jaime

AU - Rosenfeld, Ron G.

AU - Pollock, Brad H.

PY - 1994/9

Y1 - 1994/9

N2 - Primary GH insensitivity due to GH receptor deficiency (GHRD) provides a model for studying the discrete effects of severe IGF-I deficiency on growth and body composition. Growth failure in utero is doubtful, but postpartum growth proceeds at rates that result in adult statures 4-12 standard deviations (SDs) below the normal mean. Wide variability in statural effect, even in a genetically homogeneous population, is partly explained by correlation of SD score with biochemical measures of GH effect (IGF-I, IGF-II, and IGFBP-3). Growth and changes in body composition (decreased fat/lean) in patients with GHRD in response to exogenous IGF-I indicate that direct local effects of GH are not necessary for these responses.

AB - Primary GH insensitivity due to GH receptor deficiency (GHRD) provides a model for studying the discrete effects of severe IGF-I deficiency on growth and body composition. Growth failure in utero is doubtful, but postpartum growth proceeds at rates that result in adult statures 4-12 standard deviations (SDs) below the normal mean. Wide variability in statural effect, even in a genetically homogeneous population, is partly explained by correlation of SD score with biochemical measures of GH effect (IGF-I, IGF-II, and IGFBP-3). Growth and changes in body composition (decreased fat/lean) in patients with GHRD in response to exogenous IGF-I indicate that direct local effects of GH are not necessary for these responses.

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DO - 10.1016/1043-2760(94)P3205-L

M3 - Artículo de revisión

AN - SCOPUS:0028151599

SN - 1043-2760

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JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

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ER -

Growth in growth hormone insensitivity

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