High prevalence of extended-spectrum beta-lactamase ctx-m-producing Escherichia coli in small-scale poultry farming in rural Ecuador

Hayden D. Hedman, Joseph N.S. Eisenberg, Karla A. Vasco, Christopher N. Blair, Gabriel Trueba, Veronica J. Berrocal, Lixin Zhang

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

15 Citas (Scopus)

Resumen

Small-scale farming may have large impacts on the selection and spread of antimicrobial resistance to humans. We conducted an observational study to evaluate antibiotic-resistant Escherichia coli populations from poultry and humans in rural northwestern Esmeraldas, Ecuador. Our study site is a remote region with historically low resistance levels of third-generation antibiotics such cefotaxime (CTX), a clinically relevant antibiotic, in both poultry and humans. Our study revealed 1) high CTX resistance (66.1%) in farmed broiler chickens, 2) an increase in CTX resistance over time in backyard chicken not fed antibiotics (2.3-17.9%), and 3) identical blaCTX-M sequences from human and chicken bacteria, suggesting a spillover event. These findings provide evidence that small-scale meat production operations have direct impacts on the spread and selection of clinically important antibiotics among underdeveloped settings.

Idioma originalInglés
Páginas (desde-hasta)374-376
Número de páginas3
PublicaciónAmerican Journal of Tropical Medicine and Hygiene
Volumen100
N.º2
DOI
EstadoPublicada - 2019

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