Hippocampal place cell sequences differ during correct and error trials in a spatial memory task

Chenguang Zheng, Ernie Hwaun, Carlos A. Loza, Laura Lee Colgin

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

13 Citas (Scopus)

Resumen

Theta rhythms temporally coordinate sequences of hippocampal place cell ensembles during active behaviors, while sharp wave-ripples coordinate place cell sequences during rest. We investigated whether such coordination of hippocampal place cell sequences is disrupted during error trials in a delayed match-to-place task. As a reward location was learned across trials, place cell sequences developed that represented temporally compressed paths to the reward location during the approach to the reward location. Less compressed paths were represented on error trials as an incorrect stop location was approached. During rest periods of correct but not error trials, place cell sequences developed a bias to replay representations of paths ending at the correct reward location. These results support the hypothesis that coordination of place cell sequences by theta rhythms and sharp wave-ripples develops as a reward location is learned and may be important for the successful performance of a spatial memory task.

Idioma originalInglés
Número de artículo3373
PublicaciónNature Communications
Volumen12
N.º1
DOI
EstadoPublicada - 1 dic. 2021
Publicado de forma externa

Huella

Profundice en los temas de investigación de 'Hippocampal place cell sequences differ during correct and error trials in a spatial memory task'. En conjunto forman una huella única.

Citar esto