TY - JOUR
T1 - Horizontal mitochondrial transfer in cancer biology
T2 - Potential clinical relevance
AU - Berridge, Michael V.
AU - Zobalova, Renata
AU - Boukalova, Stepana
AU - Caicedo, Andrés
AU - Rushworth, Stuart A.
AU - Neuzil, Jiri
N1 - Publisher Copyright:
© 2025
PY - 2025
Y1 - 2025
N2 - Recent research highlights horizontal mitochondrial transfer as a key biological phenomenon linked to cancer onset and progression. The transfer of mitochondria and their genomes between cancer and non-cancer cells shifts our understanding of intercellular gene trafficking, increasing the metabolic fitness of cancer cells and modulating antitumor immune responses. This process not only facilitates tumor progression but also presents potential therapeutic opportunities.
AB - Recent research highlights horizontal mitochondrial transfer as a key biological phenomenon linked to cancer onset and progression. The transfer of mitochondria and their genomes between cancer and non-cancer cells shifts our understanding of intercellular gene trafficking, increasing the metabolic fitness of cancer cells and modulating antitumor immune responses. This process not only facilitates tumor progression but also presents potential therapeutic opportunities.
UR - http://www.scopus.com/inward/record.url?scp=105000676829&partnerID=8YFLogxK
U2 - 10.1016/j.ccell.2025.03.002
DO - 10.1016/j.ccell.2025.03.002
M3 - Comentario/Debate
AN - SCOPUS:105000676829
SN - 1535-6108
JO - Cancer Cell
JF - Cancer Cell
ER -
